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Pyr3 inhibits ACh-induced contraction. (a) Pyr3, a blocker of TRPC3 and Orai1 channels, partially inhibited ACh-induced contraction in a dose-dependent manner. The remained contraction was completely blocked by 1 mg/mL CEPN. The dose-response from 4 experiments is shown in (b). (c) Comparison of the relaxant effects of CEPN, nifedipine, and Pyr3 on ACh-induced contraction. ** P < 0.01, *** P < 0.001.
