Table 3.
Tobacco smoking and the risk of head and neck cancer by age group, separately according to cancer subsite. International Head and Neck Cancer Epidemiology Consortium
| Subsite | ≤45 yo |
>45 yo |
||||||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR | (95% CI) | Cases | Controls | OR | (95% CI) | |
| Oral cavity cancer | ||||||||
| Tobacco smokinga | ||||||||
| Never | 220 | 1793 | 1.00 | 1009 | 8463 | 1.00 | ||
| Ever | 519 | 2207 | 1.91 | (1.53, 2.38) | 3825 | 13 513 | 2.18 | (1.99, 2.39) |
| Missing | 2 | 12 | – | – | 17 | 25 | – | – |
| Pack-yearsa | ||||||||
| Never smoker | 220 | 1793 | 1.00 | 1009 | 8463 | 1.00 | ||
| >0 to 10 | 93 | 894 | 1.11 | (0.83, 1.49) | 293 | 277 | 0.92 | (0.79, 1.08) |
| >10 to 20 | 117 | 569 | 1.87 | (1.39, 2.51) | 361 | 2312 | 1.39 | (1.20, 1.61) |
| >20 to 30 | 129 | 397 | 2.80 | (2.06, 3.81) | 528 | 2136 | 2.22 | (1.94, 2.54) |
| >30 to 40 | 71 | 136 | 4.09 | (2.75, 6.07) | 677 | 1998 | 2.82 | (2.47, 3.21) |
| >40 to 50 | 39 | 78 | 3.73 | (2.28, 6.11) | 554 | 1413 | 3.25 | (2.82, 3.74) |
| >50 | 64 | 92 | 4.99 | (3.22, 7.73) | 1360 | 2663 | 3.49 | (3.10, 3.92) |
| Missing | 8 | 53 | – | – | 69 | 241 | – | – |
| p-trend | <0.001 | <0.001 | ||||||
| Oropharynx cancer | ||||||||
| Tobacco smokinga | ||||||||
| Never | 133 | 1793 | 1.00 | 71 | 8463 | 1.00 | ||
| Ever | 414 | 2207 | 1.86 | (1.47, 2.37) | 3755 | 13 513 | 2.77 | (2.50, 3.08) |
| Missing | 1 | 12 | – | – | 06 | 25 | – | |
| Pack –yearsa | ||||||||
| Never smoker | 133 | 1793 | 1.00 | 571 | 8463 | 1.00 | ||
| >0 to 10 | 66 | 894 | 1.01 | (0.73, 1.40) | 317 | 277 | 1.36 | (1.16, 1.58) |
| >10 to 20 | 90 | 569 | 1.81 | (1.31, 2.50) | 371 | 2312 | 1.81 | (1.56, 2.10) |
| >20 to 30 | 113 | 397 | 2.69 | (1.94, 3.72) | 503 | 2136 | 2.56 | (2.22, 2.95) |
| >30 to 40 | 60 | 136 | 4.55 | (3.02, 6.87) | 641 | 1998 | 3.39 | (2.95, 3.89) |
| >40 to 50 | 37 | 78 | 4.09 | (2.48, 6.73) | 481 | 1413 | 3.69 | (3.17, 4.29) |
| >50 | 45 | 92 | 3.99 | (2.46, 6.48) | 1396 | 2663 | 4.96 | (4.37, 5.62) |
| Missing | 4 | 53 | – | – | 52 | 241 | – | – |
| p-trend | <0.001 | <0.001 | ||||||
| Larynx cancer | ||||||||
| Tobacco smokinga | ||||||||
| Never | 23 | 1371 | 1.00 | 243 | 7048 | 1.00 | ||
| Ever | 285 | 184 | 6.34 | (3.98, 10.1) | 4237 | 11 448 | 8.31 | (7.21, 9.58) |
| Missing | 2 | 9 | – | – | 28 | 20 | – | – |
| Pack-yearsa | ||||||||
| Never smoker | 23 | 1371 | 1.00 | 243 | 7048 | 1.00 | ||
| >0 to 10 | 40 | 759 | 2.86 | (1.65, 4.97) | 229 | 2441 | 2.41 | (1.98, 2.93) |
| >10 to 20 | 48 | 481 | 5.16 | (2.99, 8.91) | 359 | 2054 | 4.35 | (3.63, 5.21) |
| >20 to 30 | 84 | 319 | 12.8 | (7.51, 22.0) | 581 | 1825 | 8.23 | (6.94, 9.76) |
| >30 to 40 | 43 | 109 | 18.6 | (10.1, 30.3) | 784 | 1718 | 11.15 | (9.44, 13.2) |
| >40 to 50 | 32 | 68 | 20.9 | (10.8, 40.8) | 684 | 1199 | 12.97 | (10.9, 15.4) |
| >50 | 33 | 69 | 20.2 | (10.4, 39.8) | 1535 | 2010 | 18.03 | (15.3, 21.1) |
| Missing | 7 | 48 | – | – | 93 | 221 | – | – |
| p-trend | <0.001 | <0.001 | ||||||
aORs adjusted on sex, age, study, education level and drink/day of alcohol (study centre as random intercept).