Table 4.
Alcohol drinking and the risk of head and neck cancer according to sex and age subgroups. International Head and Neck Cancer Epidemiology Consortium
| Alcohol drinkinga | Women ≤45 yo |
Women >45 yo |
Men ≤45 yo |
Men >45 yo |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR | (95% CI) | Case | Control | OR | (95% CI) | Case | Control | OR | (95% CI) | Case | Control | OR | (95% CI) | |
| Never | 208 | 675 | 1.00 | 1242 | 3010 | 1.00 | 171 | 533 | 1.00 | 911 | 2845 | 1.00 | ||||
| Ever | 297 | 736 | 1.10 | (0.84, 1.44) | 2263 | 3218 | 1.45 | (1.29, 1.63) | 1326 | 2051 | 1.32 | (1.06, 1.65) | 12 188 | 13 615 | 2.18 | (1.98, 2.40) |
| Missing | 0 | 27 | – | – | 17 | 10 | – | – | 8 | 20 | – | – | 73 | 42 | – | – |
| Duration (years)a | ||||||||||||||||
| Never drinker | 207 | 663 | 1.00 | 1205 | 2913 | 1.00 | 16 | 529 | 1.00 | 897 | 2774 | 1.00 | ||||
| >0 to 20 | 130 | 386 | 0.92 | (0.67, 1.26) | 282 | 434 | 1.41 | (1.15, 1.73) | 386 | 858 | 1.23 | (0.96, 1.58) | 660 | 1076 | 1.46 | (1.27, 1.69) |
| >20 to 30 | 113 | 230 | 1.34 | (0.93, 1.92) | 388 | 521 | 1.67 | (1.39, 2.02) | 708 | 945 | 1.50 | (1.17, 1.92) | 1653 | 1921 | 2.10 | (1.86, 2.37) |
| >30 to 40 | 9 | 24 | 0.67 | (0.25, 1.78) | 584 | 827 | 1.65 | (1.40, 1.94) | 12 | 105 | 1.65 | (1.13, 2.42) | 3789 | 3999 | 2.26 | (2.03, 2.52) |
| >40 to 50 | 0 | 0 | – | – | 389 | 630 | 1.24 | (1.03, 1.49) | 0 | 2 | – | – | 3183 | 3264 | 2.31 | (2.06, 2.58) |
| >50 to 60 | 0 | 0 | – | – | 160 | 248 | 1.26 | (0.97, 1.64) | 0 | 0 | – | – | 1284 | 1347 | 2.20 | (1.92, 2.51) |
| >60 | 0 | 0 | – | – | 41 | 42 | 1.33 | (0.80, 2.23) | 0 | 0 | – | – | 221 | 202 | 2.07 | (1.62, 2.65) |
| Missing | 46 | 135 | – | – | 673 | 623 | – | – | 124 | 165 | – | – | 1485 | 1919 | – | – |
| p-trend | 0.353 | <0.001 | 0.001 | <0.001 | ||||||||||||
| Frequency (drinks/day)a | ||||||||||||||||
| Never | 208 | 675 | 1.00 | 1242 | 3011 | 1.00 | 171 | 533 | 1.00 | 912 | 2850 | 1.00 | ||||
| >0 to <1 | 149 | 468 | 0.90 | (0.66, 1.22) | 1034 | 1982 | 1.12 | (0.98, 1.28) | 251 | 687 | 0.93 | (0.72, 1.21) | 1893 | 4253 | 1.17 | (1.05, 1.31) |
| 1 to <3 | 62 | 17 | 1.29 | (0.86, 1.96) | 548 | 841 | 1.59 | (1.35, 1.87) | 298 | 554 | 1.34 | (1.03, 1.75) | 2630 | 4162 | 1.72 | (1.54, 1.91) |
| 3 to <5 | 31 | 34 | 2.43 | (1.30, 4.54) | 238 | 151 | 3.34 | (2.55, 4.36) | 157 | 297 | 1.31 | (0.96, 1.79) | 1891 | 2095 | 2.62 | (2.33, 2.95) |
| ≥5 | 36 | 30 | 2.48 | (1.35, 4.55) | 301 | 66 | 5.90 | (4.32, 8.06) | 559 | 437 | 2.68 | (2.04, 3.53) | 5159 | 2660 | 4.75 | (4.26, 5.30) |
| Missing | 19 | 74 | – | – | 159 | 187 | – | – | 69 | 96 | – | – | 687 | 482 | – | – |
| p-trend | <0.001 | <0.001 | <0.001 | <0.001 | ||||||||||||
| Drinks/day x yearsa | ||||||||||||||||
| Never drinker | 208 | 650 | 1.00 | 1215 | 2925 | 1.00 | 166 | 522 | 1.00 | 869 | 2764 | 1.00 | ||||
| >0 to 20 | 143 | 452 | 0.85 | (0.62, 1.16) | 675 | 1357 | 1.15 | (0.99, 1.34) | 29 | 700 | 1.03 | (0.79, 1.33) | 1073 | 218 | 1.20 | (1.06, .36) |
| >20 to 30 | 19 | 46 | 1.62 | (0.85, 3.08) | 144 | 242 | 1.17 | (0.90, 1.16) | 62 | 162 | 0.99 | (0.68, 1.46) | 442 | 816 | 1.44 | (1.23, 1.69) |
| >30 to 40 | 12 | 34 | 0.95 | (0.42, 2.11) | 99 | 182 | 1.23 | (0.91, 1.66) | 68 | 130 | 1.31 | (0.89, 1.93) | 392 | 751 | 1.43 | (1.21, 1.68) |
| >40 to 50 | 10 | 32 | 1.25 | (0.51, 3.03) | 81 | 176 | 1.23 | (0.89, 1.71) | 45 | 106 | 1.14 | (0.73, 1.77) | 352 | 618 | 1.50 | (1.26, 1.78) |
| >50 to 60 | 6 | 7 | 4.21 | (1.23, 14.4) | 81 | 126 | 1.39 | (0.99, 1.96) | 46 | 46 | 1.19 | (0.76, 1.85) | 339 | 548 | 1.61 | (1.35, 1.93) |
| >60 | 56 | 48 | 2.78 | (1.63, 4.74) | 684 | 553 | 2.79 | (2.34, 3.34) | 696 | 663 | 2.31 | (1.77, 3.03) | 7824 | 6320 | 2.99 | (2.70, 3.32) |
| Missing | 55 | 169 | – | – | 543 | 677 | – | – | 163 | 223 | – | – | 1881 | 2167 | – | – |
| p-trend | <0.001 | <0.001 | <0.001 | <0.001 | ||||||||||||
aORs adjusted by sex, race, age, education level and pack-year of cigarette smoking (study centre as random intercept).