Table 5.
Alcohol drinking and the risk of head and neck cancer by age group, separately according to cancer subsite. International Head and Neck Cancer Epidemiology Consortium
| Subsite | ≤45 years old |
>45 years old |
||||||
|---|---|---|---|---|---|---|---|---|
| Case | Control | OR | (95% CI) | Case | Control | OR | (95% CI) | |
| Oral cavity cancer | ||||||||
| Alcohol drinkinga | ||||||||
| Never | 183 | 207 | 1.00 | 911 | 5830 | 1.00 | ||
| Ever | 557 | 2758 | 1.24 | (0.97, 1.57) | 3919 | 16 119 | 1.61 | (1.46, 1.79) |
| Missing | 1 | 47 | 21 | |||||
| Frequency (drinks/day)a | ||||||||
| Never drinker | 183 | 1207 | 1.00 | 912 | 5836 | 1.00 | ||
| >0 to <1 | 131 | 1144 | 0.79 | (0.59, 1.07) | 900 | 6026 | 0.99 | (0.88, 1.12) |
| 1 to <3 | 126 | 705 | 1.39 | (1.01, 1.90) | 842 | 4745 | 1.34 | (1.18, 1.52) |
| 3 to <5 | 62 | 323 | 1.49 | (1.01, 2.20) | 524 | 2101 | 2.12 | (1.83, 2.46) |
| ≥5 | 196 | 464 | 2.77 | (2.01, 3.83) | 1380 | 2630 | 3.71 | (3.25, 4.23) |
| Missing | 43 | 169 | – | – | 293 | 663 | – | – |
| p-trend | <0.001 | <0.001 | ||||||
| Oropharynx cancer | ||||||||
| Alcohol drinkinga | ||||||||
| Never | 83 | 207 | 1.00 | 447 | 5830 | 1.00 | ||
| Ever | 464 | 2758 | 1.66 | (1.25, 2.21) | 3875 | 16 781 | 2.16 | (1.92, 2.44) |
| Missing | 1 | 47 | – | – | 10 | 52 | – | – |
| Frequency (drinks/day)a | ||||||||
| Never drinker | 83 | 207 | 1.00 | 447 | 5836 | 1.00 | ||
| >0 to <1 | 135 | 1144 | 1.24 | (0.90, 1.72) | 823 | 6026 | 1.28 | (1.11, 1.47) |
| 1 to <3 | 99 | 705 | 1.55 | (1.09, 2.21) | 819 | 4745 | 1.83 | (1.59, 2.11) |
| 3 to <5 | 43 | 323 | 1.40 | (0.98, 2.41) | 580 | 2101 | 3.13 | (2.67, 3.66) |
| ≥5 | 171 | 464 | 4.30 | (2.98, 6.20) | 1452 | 2630 | 5.68 | (4.91, 6.55) |
| Missing | 17 | 169 | – | – | 211 | 663 | – | – |
| p-trend | <0.001 | <0.001 | ||||||
| Larynx cancer | ||||||||
| Alcohol drinkinga | ||||||||
| Never | 38 | 97 | 1.00 | 465 | 4698 | 1.00 | ||
| Ever | 268 | 2270 | 1.25 | (0.83, 1.87) | 3999 | 13 781 | 1.90 | (1.41, 1.80) |
| Missing | 4 | 7 | – | – | 44 | 37 | – | – |
| Frequency (drinks/day)a | ||||||||
| Never drinker | 38 | 947 | 1.00 | 465 | 4704 | 1.00 | ||
| >0 to <1 | 5 | 889 | 0.89 | (0.55, 1.44) | 762 | 4726 | 1.03 | (0.89, 1.19) |
| 1 to <3 | 61 | 600 | 1.21 | (0.75, 1.95) | 961 | 4308 | 1.29 | (1.12, 1.48) |
| 3 to <5 | 40 | 296 | 1.33 | (0.77, 2.27) | 641 | 2016 | 1.76 | (1.50, 2.06) |
| ≥5 | 105 | 411 | 1.81 | (1.13, 2.90) | 1496 | 2372 | 2.82 | (2.40, 3.25) |
| Missing | 11 | 81 | – | – | 183 | 390 | – | – |
| p-trend | <0.001 | <0.001 | ||||||
aORs adjusted on sex, age, study, education level and pack-years of cigarette smoking (study centre as random intercept).