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. 2014 Dec 19;138(3):549–562. doi: 10.1093/brain/awu344

Figure 2.

Figure 2

Lesion localization. Proximal to distal mapping of lesion-voxels-numbers within the tibial nerve [slice positions 0 (= proximal thigh) to 139 (= tibiotalar joint)]. Mean frequencies of lesion voxel number within the tibial nerve were calculated and referenced to the control group which was set as baseline. Note the predominant and statistically significant proximal focus of nerve lesions at thigh level in both, the manifest TTR-FAP patients (TTR+-FAP+, squares) and the asymptomatic gene carriers (TTR+-FAP−, circles). Differences in the proximal lesion voxel number between manifest TTR-FAP and gene carriers were also highly significant.