Table 1.
Patient characteristics
| A−V− | A−V+ | A+V+ | A+V− | P-value | |
|---|---|---|---|---|---|
| No. of subjects (%) | 178 (45) | 89 (23) | 45 (11) | 81 (21) | |
| No. of Females (%) | 85 (48) | 41 (46) | 19 (42) | 33 (41) | 0.73 |
| Age (years) | 76 (73, 81) | 78 (75, 83) | 82 (79, 83) | 78 (75, 81) | <0.001 |
| No. of ε4 carriers (%) | 34 (19) | 17 (19) | 15 (33) | 40 (49) | <0.001 |
| Education (years) | 13.5 (12, 16) | 14 (12, 16) | 13 (12, 16) | 14 (12, 16) | 0.48 |
| Short Test of mental status | 35.5 (34, 37) | 35 (34, 37) | 34 (32, 36) | 35 (33, 36) | 0.17 |
| Global z-score | 0.80 (0.19, 1.34) | 0.71 (0.24, 1.07) | 0.08 (−0.36, 0.59) | 0.64 (0.13, 1.26) | 0.002 |
| Job Score | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 4 (3, 6) | 0.97 |
| Global cortical PIB | 1.33 (1.29, 1.38) | 1.34 (1.30, 1.38) | 1.93 (1.64, 2.22) | 1.86 (1.68, 2.11) | |
| Mid-life intellectual score | 21 (15.5, 27.5) | 20 (14.5, 28) | 21 (15.5, 27) | 21 (14, 24.5) | 0.84 |
| Late-life intellectual score | 23.5 (17.5, 30.5) | 23 (15, 30.5) | 23 (17.5, 30.5) | 21 (16, 28) | 0.35 |
| WMH/TIV % | 0.48 (0.36, 0.67) | 1.12 (0.59, 1.58) | 1.19 (0.87, 1.73) | 0.46 (0.35, 0.68) | |
| No. with cortical infarctions (%) | 0 | 11 (12) | 9 (20) | 0 | |
| No. with subcortical infarctions (%) | 0 | 55 (62) | 21 (47) | 0 | |
| Baseline visit number | 2 (1, 4) | 3 (1, 4) | 4 (3, 5) | 3 (1, 4) | <0.001 |
| Follow-up (years) | 2.7 (1.0, 7.7) | 2.8 (1.2, 6.7) | 2.7 (1.2, 6.9) | 2.7 (1.2, 6.6) | 0.49 |
| No of progressors to mild cognitive impairment/dementia (%) | 22 (12) | 14 (16) | 16 (36) | 14 (17) | 0.003 |