Table 2.

Parsimonious model, random subject-specific intercepts and slopes

	Coefficient	Standard error	P-value
(Intercept)	5.00	0.68	<0.0001
Baseline age (years)	−0.05	0.01	<0.0001
Males	−0.37	0.08	<0.0001
Time (years)	0.56	0.12	<0.0001
Education/occupation score	0.26	0.04	<0.0001
Baseline visit number	0.10	0.02	<0.0001
Amyloid pathway	−0.17	0.08	0.0386
Vascular pathway	−0.10	0.08	0.2223
Baseline age × time	−0.0073	0.0016	<0.0001
Amyloid pathway × time	−0.06	0.02	0.0003
Vascular pathway × time	−0.05	0.02	0.0037

From a mixed effects model that predicts longitudinal global cognitive z-scores with demographics and presence or absence of pathologies as predictors.