Table 4.
BMI GWAS SNPs for BMI Differentially Expressed Genes linking by eQTLs
| Gene -- Trait | SNP -- Gene | SNP -- Trait | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Chr. for gene |
eQTL | SNP Location | Signature P value |
Signature FDR |
Phenotypic Proportion (Gene for Trait) |
eSNP p value |
Cis Trans |
Phenotypic Proportion (SNP for Gene) |
‡GWAS - p value |
Phenotypic Proportion (SNP for Trait) |
||
| ETV5 | chr3 | rs9816226 | Intronic (DGKG) | 0.01 | 0.0002 | 0.001 | 0.003 | 4.44E-16 | cis | 0.012 | 7.61E-14 | 1.5E-4 | |
| AAGAB | chr15 | rs2278076 | 3' downstream (MAP2K5) |
0.04 | 0.0003 | 0.002 | 0.001 | 6.08E-06 | cis | 0.004 | 1.46E-10 | 0 | |
| CLN6 | chr15 | rs3784707 | Intronic (MAP2K5) |
0.17 | 1.35E-10 | 2.58E-09 | 0.008 | 9.66E-06 | cis | 0.004 | 1.46E-10 | 0 | |
| SULT1A1 | chr16 | rs7498665 | Coding (SH2B1) | 0.21 | 0.01 | 0.05 | 0.001 | 5.54E-07 | cis | 0.006 | 1.75E-10 | 8.6E-5 | |
| SPNS1 | 0.05 | 8.25E-05 | 5.57E-04 | 0.004 | 5.77E-15 | cis | 0.012 | ||||||
| TUFM | 0.19 | 0.007 | 0.03 | 0.002 | 5.16E-08 | cis | 0.148 | ||||||
| PTPRJ | chr11 | rs2290851 | Intronic (FNBP4) | 0.19 | 1.28E-17 | 5.79E-16 | 0.014 | 3.88E-07 | cis | 0.005 | 2.77E-10 | 4.5E-4 | |
| MTCH2 | 0.08 | 1.13E-05 | 9.26E-05 | 0.003 | 3.60E-14 | cis | 0.011 | ||||||
| LIN7C | chr11 | rs1519480 | 3' downstream (BDNF) |
0.08 | 2.55E-06 | 2.39E-05 | 0.004 | 2.22E-14 | cis | 0.012 | 2.12E-09 | 4.4E-4 | |
GWAS-p value: for BMI, the p values are from GIANT (Speliotes et al. 2010);