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. 2015 Jan 30;4(3):230–238. doi: 10.5966/sctm.2014-0127

Figure 1.

Figure 1.

NPC1 induced pluripotent stem cell (iPSC)-derived NSCs do not display major disease-specific differences from control line NSCs. (A): NPC1 subject iPSCs express the stem cell-specific markers OCT4, TRA-1-60, and NANOG, shown in green (images at ×10). (B): NPC1 and NCRM-1 NSCs express NSC markers NESTIN and SOX2, shown in green (images at ×20). (C): Gene signal intensity for NPC1 and NCRM-1 NSCs displays an R2 value of 0.96, suggesting high overlap in gene expression between these two cell types. Abbreviations: AVG, average; NPC1, Niemann-Pick disease, type C1; NSC, neural stem cell.