Figure 4.

Drug treatment on NPC1 and NCRM-1 neurons supports roles of calcium and WNT signaling in NPC1 neuronal cell death. (A): NPC1 neuronal cell death can be rescued by the addition of curcumin, dantrolene, and WNT agonists. Percentages were calculated in relation to treatment with medium without drug. (B): Representative images of NPC1 and NCRM-1 neuronal survival with or without curcumin at day 14 reveal NPC1 neuronal death can be rescued by single early dose of drug. All images are at ×10. Abbreviation: NPC1, Niemann-Pick disease, type C1.