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. 2014 Nov 11;21(3):296–308. doi: 10.1093/molehr/gau105

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© The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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HIF-2α localization in first trimester placentas collected by a CVS-like technique (A), collected by CVS and then cultured for 6 h (B), or collected by curettage (C). Representative images of HIF-2α staining are shown. Gestational age is indicated in each representative image in A and B, and culture conditions are indicated in C. Brown colour signifies positive staining. HIF-2α was almost undetectable in the CVS tissue (A) whilst a prominent cytotrophoblast and syncytiotrophoblast nuclear staining was detected in all curettage specimens (B) and in cultured explants (C). Scale bar = 50 µm. ST, arrow points to a syncytiotrophoblast nucleus; CT, arrow points to a cytotrophoblast nucleus.