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. Author manuscript; available in PMC: 2015 Feb 25.
Published in final edited form as: Cancer Res. 2012 Sep 19;72(22):5790–5800. doi: 10.1158/0008-5472.CAN-12-0818

Figure 4.

Figure 4

Two intronic XREs are responsible for transactivation of ADM by AHR. (A) 12 putative XREs (orange ovals) were found across the entire genomic sequence of the ADM gene. (B) The two XREs contained in the first intron of the ADM gene are largely responsible for its transactivation in A549 cells and AHR+/+ fibroblasts exposed to CSE (0.06 puffs/ml). (C) Single mutation of the XREs present in this region results in significant diminution of ADM transactivation in both A549 and AHR wild type cells exposed to CSE (0.06 puffs/ml). Mutation of both XREs further impedes ADM transactivation. Exons are indicated green boxes.