Table 3.
CCTA Findings and Study Endpoints in All Patients and Those with High CAC Scores
| CAC score | All (n=473) | >400 (n=35) | >600 (n=23) | >800 (n=17) | >1000 (n=11) |
|---|---|---|---|---|---|
| CCTA Findings | |||||
| Interpretable CCTA (%) | 453 (96) | 32 (91) | 20 (87) | 14 (82) | 8 (73) |
| Obstructive CAD by 50% Threshold | 82 (17) | 30 (86) | 18 (78) | 14 (82) | 8 (73) |
| Obstructive CAD by 70% Threshold | 52 (11) | 28 (80) | 17 (74) | 13 (76) | 7 (64) |
| Primary and Secondary Endpoints | |||||
| Length of Stay, hours median [25th, 75th %ile] | 8.5 [6.3, 26.8] | 47.9 [29.2, 76.8] | 32.2 [26.7, 78.0] | 47.9 [29.2, 76.5] | 47.9 [26.7, 78.0] |
| Discharge status (%) | |||||
| Direct ED Discharge | 230 (49) | 4 (11) | 4 (17) | 2 (12) | 2 (18) |
| Admission to observational unit | 140 (30) | 5 (14) | 3 (13) | 2 (12) | 1 (9) |
| Admission to hospital | 98 (21) | 26 (74) | 16 (70) | 13 (76) | 8 (73) |
| Left against medical advice | 5 (1) | 0 | 0 | 0 | 0 |
|
| |||||
| Downstream Testing During Index Visit n (%) / At 28-days Follow-up n (%) | |||||
| Subsequent Stress Testing | |||||
| ETT | 10(2) / 20(4) | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 |
| Nuclear | 42(9) / 50(11) | 7(20) / 8(23) | 3(13) / 4(17) | 3(18) / 3(18) | 2(18) / 2(18) |
| Stress Echo | 13(3)/ 13(3) | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 |
|
| |||||
| Invasive Coronary Angiography (ICA) | 51(11) / 56(12) | 20(57) / 23(66) | 12(52) / 13(57) | 10(59) /11(65) | 5(45) / 6(55) |
|
| |||||
| ICA with >50% stenosis | 36(8) / 40(8) | 17(49) / 19(54) | 11(48) / 12(52) | 9(53) / 10(59) | 5(45) / 6(55) |
| Interventions During Index Visit, n (%)/ At 28-days Follow-up n (%) | |||||
|
| |||||
| PCI | 27 (6) / 25 (5) | 11 (31) / 12 (34) | 5 (22) / 5 (22) | 4 (24) / 4 (24) | 3 (27) / 3 (27) |
| PCI/CABG | 27 (6) / 30 (6) | 12 (34) / 11 (31) | 5 (22) / 5 (22) | 4 (24) / 4 (24) | 3 (27) / 3 (27) |
|
| |||||
| ACS (%) | 38 (8) | 17 (49) | 9 (39) | 8 (47) | 5 (45) |
| 28-day MACE (%) | 2 (0.4) | 1 (3) | 0 | 0 | 0 |
Abbreviations as in Table 1. ETT denotes exercise treadmill test; Echo, echocardiography; PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft; and MACE, major adverse cardiovascular event.