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. 2015 Mar;22(3):159–169. doi: 10.1101/lm.037770.114

Figure 1.

Figure 1.

CsA does not affect initial learning of contextual fear conditioning. (A) Mean time spent freezing (%) (±SEM) by mice treated with CHX (100 mg/kg) or saline 30 min before the conditioning session, during the preshock period of the training session (preshock) and during the test session 24 h later, showing a significant effect of the drug on memory formation (n = 15 (CHX), 18 (DMSO); Student's t test, P = 0.003); (**) P < 0.01. (B) Mean time spent freezing by mice treated with CsA (20 mg/kg) or vehicle (DMSO) 60 min before the conditioning session, during the preshock period of the training session and during the test session 24 h later. There was no significant difference in freezing between groups (n = 16 (CsA), 15 (DMSO); Student's t test, P = 0.43); (C) Mean time spent freezing by mice treated with CsA or vehicle as in B, but with the test session performed 30 min after the end of training. There was no significant difference in freezing between groups (n = 11 (CsA), 13 (DMSO); Student's t test, P = 0.49).