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. Author manuscript; available in PMC: 2015 Feb 25.
Published in final edited form as: Inflamm Bowel Dis. 2014 Jul;20(7):1259–1287. doi: 10.1097/MIB.0000000000000047

Table 6.

Purinergic drugs for treating inflammation-induced diarrhea in experimental models

Drug Purinergic target Model References
ATL-801 (78) A2B antagonist DSS colitis, IL-10 KO spontaneous colitis Kolachala V et al, 2008 96 (ameliorates colitis)
PSB-1115 (27) A2B antagonist DSS colitis Frick JS et al, 2009 68 (exacerbates colitis)
IB-MECA (9) A3 agonist IL-10 KO, DSS colitis Gessi S et al, 2008 242
ATL-146e (69) A2A agonist Rabbit colitis, spont. Ileitis in SAMP1/YitFc mice Odashima M et al, 2005132
4-amino-2-(2-hydroxyl-1-decyl) pyrazole[3,4-d]pyrimidine (APP) (63) AdoDase inhibitor DNBS-induced colitis Antonioli L et al, 2007 49
Pentostatin (62) AdoDase inhibitor Severe IL-10−/− colitis with piroxicam-induced colitis Brown JB et al, 2008 243
Dipyridamole (61) ENT1, ENT2 inhibitor LPS/phytohaemagglutinin-induced gut mononuclear cells from CD patients Poturoglu S et al, 2009 83
MRS2500 (51) P2Y1 antagonist Neurogenic secretion model (in vitro) Fang X et al, 2006 103