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. 2015 Feb 25;6:58. doi: 10.3389/fgene.2015.00058

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Copyright © 2015 Smith, Therrien, Filion, Bressan and Meirelles.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DNA methylation pattern of the paternal H19/IGF2 DMR in hybrid fibroblasts (somatic cell) and induced pluripotent stem (iPS) cells. Circles represent methylated (black) and non-methylated (white) CpGs on the paternal allele DMR as confirmed by a Bos indicus-specific SNP (vertical arrow). Square indicates location of the CTCF binding site also indicating significant de-methylation after iPS cell reprogramming.