Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 6;16:1. doi: 10.1186/s12860-015-0047-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Sokołowska et al.; licensee Biomed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Decreased hydrophobicity of BACE457 impairs its interactions with EDEM1 and EDEM2. Co-immunoprecipitation of BACE457 or BACE457_DHF with anti-HA antibodies from cells overexpressing EDEM1-HA (A) or EDEM2-HA (B). Representative examples of the experiments are shown. Membranes were re-probed with anti-HA antibodies to confirm equal immunoprecipitation. Whole cell lysates (WCL) analysed with anti-BACE antibodies are shown in the bottom panel. (C), (D) Graphs of the average data presented in (A) and (B) with s.d. from three independent experiments are shown. The level of immunoprecipitated BACE457 from EDEM1-transfected cells or EDEM2- transfected cells is marked as 1, the level of immunoprecipitated BACE457 DHF is relative to this value.