TABLE 1.

Selected mouse models of intestinal TAG metabolism

Gene	Tissues with High Expression	Genetic Manipulation	Phenotype	Reference
Mogat2	Small intestine	Global knockout	Delayed fat absorption	(119, 122)
			Increased energy expenditure
			Protection from obesity induced by diet or the agouti mutation
		Intestine-specific deletion	Delayed fat absorption	(36)
			Partial protection from diet-induced obesity
		Intestine-specific expression	Restored fat absorption rate	(37)
			Partial recovery of weight gain and metabolic efficiency when fed a high-fat diet
Dgat1	Small intestine, adipose tissue and mammary gland	Global knockout	Delayed fat absorption	(85, 87)
			Increased energy expenditure
			Protection from obesity induced by diet or the agouti mutation
		Intestine-specific expression	Restored fat absorption rate	(113)
			Recovery of weight gain and hepatic steatosis induced by high-fat feeding
Dgat2	Liver, adipose tissue and mammary gland	Global knockout	Death shortly after birth with severe deficiency in energy substrates and skin barrier defect	(88)
		Intestine-specific over-expression	Increased TG secretion	(114)
			Exacerbated hepatic steatosis
MTP	Liver and intestine	Conditional intestine-specific deletion	Reduced chylomicron secretion	(120)
			Large lipid droplets in enterocytes
			Steatorrhea
ApoB	Liver and intestine	Intestine specific deletion	Defect in chylomicron production	(121)
			Fat malabsorption
ATGL	Adipose tissue	Intestine specific deletion	Increased cytosolic lipid droplets in enterocytes Increased fecal fat	(106)
CGI-58	Adipose tissue and testes	Intestine specific deletion	Decreased fat absorption	(107)
			Increased fecal fat
			TAG accumulation in enterocytes
Cideb	Liver and intestine	Global knockout	Protection from diet-induced obesity	(108, 134)
			Increased energy expenditure
			Reduced chylomicron secretion