Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of IC50 values of MGAT2 inhibitors obtained using the cell-based assay and the in vitro enzyme assay
| Compound | IC50 (nM) | Fold Difference Cell-Based Assay/In Vitro Assay | |
| Cell-Based Assay | In Vitro Enzyme Assay | ||
| XP-620 | >10,000 | >10,000 | |
| Compound B | 0.6 | 0.9 | 0.7 |
| Compound C | 1.5 | 1.9 | 0.8 |
| Compound D | 235 | 179 | 1.3 |
| Compound E | 99 | 45 | 2.2 |
| Compound F | 112 | 28 | 4.0 |
| Compound G | 33 | 3.7 | 8.9 |
| Compound H | 624 | 19 | 32.8 |
| Compound I | 166 | 4.9 | 33.9 |
| Compound J | 1,646 | 43 | 38.3 |
