Table 1.
PANDAS Criteria by Site
| NIMH (n=48) | Hinsdale (n=52) | Bethesda (n=40) | ||||
|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | |
| 1. Prepubertal symptom onset | ||||||
| Age at PANDAS first episode | 8.22 | 2.39 | 6.66 | 2.62 | 6.98 | 3.09 |
| Age at site evaluation | 8.58 | 2.38 | 9.19 | 2.96 | 8.48 | 2.43 |
| # | % | # | % | # | % | |
| Males | 29 | 60% | 37 | 71% | 29 | 73% |
| Females | 19 | 40% | 15 | 29% | 11 | 27% |
| 2. Presence of OCD and/or a tic disorder | ||||||
| 48 | 100% | 52 | 100% | 40 | 100% | |
| 3. Acute symptom onset and episodic (relapsing-remitting) course | ||||||
| Acute symptom onset | 48 | 100% | 52 | 100% | 40 | 100% |
| 4. Association with neurological abnormalities | ||||||
| 48 | 100% | 52 | 100% | 40 | 100% | |
| 5. Temporal association between GABHS infection and symptom onset/exacerbations | ||||||
| Documented evidence of exposure | 48 | 100% | 42 | 81% | 30 | 76% |
| a. Positive GAS culture | 20 | 42% | 6 | 12% | 7 | 18% |
| b. High ASO and/or DNAse-B titer | 22 | 46% | 28 | 54% | 16 | 40% |
| c. Other evidence of exposure | 6 | 12% | 8 | 15% | 7 | 18% |
| No evidence of GABHS | - | - | 4 | 8% | 5 | 12% |
| Data not found in chart | - | - | 6 | 11% | 5 | 12% |
PANDAS, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections; NIMH, National Institute of Mental Health; OCD, obsessive-compulsive disorder; GABHS, Group A beta-hemolytic streptococcus; GAS, Group A streptococcus; ASO, antistreptolysin O; DNAse-B, deoxyribonuclease-B.