Table 6.
Recent studies comparing the performances of apheresis devices for HSPC harvesting
| Reference (year) | Goal | Number of procedures | Results |
|---|---|---|---|
| Altuntas et al85 (2007) | Compare Amicus and COM.TEC performances | Amicus: 20 COM.TEC: 20 |
No difference in numbers of CD34+ cells harvested Higher decrease in PB platelets with COM.TEC |
| Reinhardt et al86 (2011) | Evaluate performances of Spectra Optia and comparison with historical performances of COBE Spectra | Spectra Optia: 35 COBE Spectra: 401 |
Excellent usability of Spectra Optia CE2 superior with Spectra Optia |
| Wu et al82 (2012) | Compare HSPC harvest using COBE Spectra, MCS+ Haemonetics, and Baxter Amicus | COBE Spectra: 99 MCS+: 81 Amicus: 38 |
Similar number of CD34+ cells harvested Better correlation of harvested/circulating HSPCs with COBE Spectra. Amicus collected less platelets |
| Brauninger et al87 (2012) | Compare Spectra Optia and COBE Spectra performances | Spectra Optia: 50 COBE Spectra: 89 |
With Optia – CE1: 7.9% greater – Less platelets but more granulocytes in products |
| Flommersfeld et al88 (2013) | Compare COM.TEC, COBE Spectra, and Spectra Optia | COM-TEC: 77 Spectra Optia: 52 COBE Spectra: 58 |
With Optia: – Higher CE – Longer duration |
| Ikeda et al89 (2014) | Compare Spectra-MNC (manual) and Spectra Auto-PBSC performances | Spectra-Auto: 118 Spectra-MNC: 70 |
Correlation between circulating HSPCs and harvested HSPCs in Spectra – MNC Less reduction in PB platelets in Spectra-Auto |
| Cherqaoui et al90 (2014) | Compare Spectra Optia and COBE Spectra performances in low-weight children | Spectra Optia: 8 COBE Spectra: 22 |
Similar CE Reduced platelet and Hb loss with Spectra Optia but higher duration |
Note: Two collection efficiency (CE) indexes are described: CD34 CE1 (%) = absolute number of CD34+ cells harvested (×100%)/([pre-apheresis CD34+ blood levels + post-apheresis CD34+ blood levels]/2) × total processed volume; CD34 CE2 (%) = absolute number of CD34+ cells harvested (×100%)/pre-apheresis CD34+ blood levels × total processed volume.
Abbreviations: Hb, hemoglobin; HSPC, hematopoietic stem and progenitor cell; PB, peripheral blood.