Table 2.
Changes in headache outcomes, pain, and headache-related disability
| Measure | Mean (SD)
|
P-value | ||
|---|---|---|---|---|
| Baseline (n=32) | Week 24 (n=26) | Change from baseline to week 24 (n=25) | ||
| Headache- or migraine-free days per 30-day period | 13.2 (5.5)b | 21.6 (5.4)c | 8.2 (5.8) | <0.0001 |
| Days with headache/migraine per 30-day period | 16.8 (5.5)b | 8.4 (5.4)c | −8.2 (5.8) | <0.0001 |
| Intensity of headache/migraine pain per 30-day perioda | 2.1 (0.4)b | 1.9 (0.4)c,d | −0.2 (0.4)e | 0.0732 |
| Pain score (VAS) | 6.2 (1.5) | 3.8 (2.8)b | −2.5 (2.5) | <0.0001 |
| Total HIT-6 score | 65.3 (4.0) | 59.2 (7.1)b | −6.3 (6.9) | 0.0001 |
| Total MIDAS score | 73.2 (58.2)e | 27.2 (37.6)d | −44.2 (67.5)e | 0.0058 |
Notes:
a
Patients scored headache pain intensity as: 1= mild, 3= moderate, or 5= severe
b
data are missing for one patient
c
average value for the three consecutive 30-day periods preceding the assessment
d
data are missing for two patients
e
data are missing for three patients.
Abbreviations: HIT-6, Headache Impact Test; MIDAS, Migraine Disability Assessment; SD, standard deviation; VAS, visual analog scale.