Life span, cardiac TG content, and metabolic parameters of WT and CM-Plin5 mice.
a, Kaplan-Meier plot showing the cumulative survival of CM-Plin5 transgenic mice compared with ATGL-deficient mice (ATGL-KO) over a period of 400 days (n = 12–21). b, cardiac TG levels in 12-week-old nonfasted and fasted WT and CM-Plin5 mice (n ≥ 4). c, body mass composition determined in 12-week-old WT and CM-Plin5 mice compared with WT (n = 5). d, food intake of 12-week-old CM-Plin5 mice compared with WT (n = 5). e, respiratory exchange quotient of 12-week-old WT and CM-Plin5 mice (n = 5). Data are shown as mean ± S.D. *, p < 0.05; **, p < 0.01 and ***, p < 0.001 compared with WT; ##, p < 0.01 compared with nonfasted state.