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. 2014 Nov 22;290(3):1295–1306. doi: 10.1074/jbc.M114.604744

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FIGURE 7. — Proposed scheme depicting the impact of PKA phosphorylation of Plin5 on the regulation of TG breakdown from Plin5-containing LDs. In the nonfasted state, Plin5 recruits and binds CGI-58. Upon fasting and the concomitant rise in cAMP, active PKA phosphorylates Plin5, leading to the release of CGI-58 from Plin5, a prerequisite required for the CGI-58-mediated stimulation of the TG hydrolytic activity of ATGL. Results from this study strongly suggest that PKA phosphorylation of Plin5 at serine 155 triggers the release of CGI-58 from Plin5 binding.