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. 2014 Dec 1;290(3):1332–1347. doi: 10.1074/jbc.M114.597948

FIGURE 2.

FIGURE 2.

Protein alignment of Cdc7 orthologs. Alignment of Drosophila Cdc7 with Cdc7 orthologs as follows: S. cerevisiae Cdc7, CAA98574.1; S. pombe Hsk1, NP_596328.1; S. pombe Spo4, NP_596598; X. laevis Cdc7, AAD21532.1; M. musculus Cdc7, AAH80702.1; H. sapiens Cdc7, AAC52080.1; D. melanogaster CG5790, NP_609876.2; and D. melanogaster lethal(1)G0148 (Cdc7), AAF46180.2. The locations of conserved kinase subdomains I to XI are noted, along with the locations of Cdc7-specific kinase insert domains 1–3. Identical residues are indicated by an asterisk, and highly similar residues are indicated by a colon. An arrow indicates the location of a substitution mutation, D269N, in a conserved kinase motif within Cdc7.