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. 2014 Dec 2;290(3):1570–1579. doi: 10.1074/jbc.M114.612085

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FIGURE 4. — ErbB2 intracellular regions are sufficient to confer kinase activator role relative to ErbB1. A, Western blots of whole cell lysates from S2R+ cells transiently transfected with normal and kinase-deficient (KD) variants of ErbB1 (B1), ErbB2 (B2), and the ErbB chimera depicted in Fig. 3A. Antibodies against phospho-Tyr¹⁰⁶⁸ (pY1068; ErbB1), phospho-Tyr^1221/1222 (pY1221/2; ErbB2), and the ErbB1 (B1-Cyto) and ErbB2 (B2-Cyto) cytoplasmic regions were used as indicated. B–D, schematic representations of phosphorylation patterns observed in A. Phosphorylation is indicated by black dots.