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. 2014 Dec 1;290(3):1580–1591. doi: 10.1074/jbc.M114.609834

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FIGURE 6. — BAP1 suppresses PRC1-mediated activation of FoxK2 target genes. A–D, codepletion of BAP1 with Ring1B or Bmi1. BAP1 and Ring1B (A and B) or Bmi1 (C and D) were depleted individually or in combination. Verification of knockdown by Western blotting is shown in A and C. β-actin served as a loading control. Expression of the indicated FoxK2 target genes was assessed by RT-PCR and is shown in B and D. Values were normalized to GAPDH and are shown relative to the control RNAi sample. qPCR was done in triplicate, and mean ± S.D. is shown. E, model of BAP1-mediated regulation of FoxK2 target genes. See “Discussion” for details.