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. 2014 Dec 4;290(3):1623–1638. doi: 10.1074/jbc.M114.592626

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FIGURE 1. — Up-regulation of HSPA1A expression in human A375 malignant melanoma cells exposed to aurin. A, chemical structures of test compounds (aurin (A), ATA, pararosaniline chloride (PRC), phenol red (PR), celastrol (Cel), geldanamycin (Gel). B, modulation of HSPA1A mRNA levels in A375 cells exposed to test compounds (A, ATA, pararosaniline chloride, and phenol red, 10 μm; celastrol and geldanamycin, 1 μm; 24 h) as determined by real time RT-PCR analysis. C, modulation of Hsp70 protein levels cells as assessed by immunoblot analysis (conditions as in panel B).