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. 2015 Feb 18;10:1449–1462. doi: 10.2147/IJN.S76134

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© 2015 Lojk et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Internalization pathways of PAA-coated Co-ferrite NPs observed with TEM in three cell types: CHO cells (A, D, G), B16 cells (B, E, H), and MYO cells (C, F, I).

Notes: For all three cell types, two endocytic pathways were observed, namely macropinocytosis (A–C) and clathrin-dependent endocytosis, for which CCP (D–F) and CCV (G–I) were observed. Scale bars correspond to 1 μm in panels (A and B), 500 nm in (C), and 250 nm in (D–I).

Abbreviations: B16, mouse melanoma cell line; CCV, clathrin-coated vesicles; CHO, Chinese Hamster Ovary cell line; Co-ferrite, cobalt ferrite; CCP, clathrin-coated pits; MYO, primary human myoblasts; NP, nanoparticle; PAA, polyacrylic acid; TEM, transmission electron microscope.