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. 2015 Feb 18;10:1449–1462. doi: 10.2147/IJN.S76134

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© 2015 Lojk et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Intracellular trafficking of PAA coated Co-ferrite NPs as observed with TEM in three selected cell types: CHO cells (A, D, G, J), B16 cells (B, E, H, K), and MYO cells (C, F, I, L).

Notes: Internalized NPs took the same intracellular trafficking route in all observed cells: inside the cytosol, NPs were found in early endosomes (A–C), late endosomes (D–F), amphisomes (G–I), and also lysosomes (J–L). Scale bars correspond to 250 nm in Figures (A–H, J–L) and to 1 μm in Figure (I).

Abbreviations: B16, mouse melanoma cell line; CHO, Chinese Hamster Ovary cell line; Co-ferrite, cobalt ferrite; MYO, primary human myoblasts; NP, nanoparticle; PAA, polyacrylic acid; TEM, transmission electron microscope.