Skip to main content
. Author manuscript; available in PMC: 2016 Jan 6.
Published in final edited form as: Cell Metab. 2015 Jan 6;21(1):138–149. doi: 10.1016/j.cmet.2014.12.014

Figure 4. Diagrammatic representation of the interactions between epigenetically conserved and genetically-associated genes implicated in this study.

Figure 4

Generated using QIAGEN’s Ingenuity IPA (Ingenuity® Systems, www.ingenuity.com), these diagrams represent the connections between genes implicated in our analyses. A) Genes with genome-wide significant linkage to T2D in the DIAGRAM meta-analysis were connected to genes near directionally conserved cross-species DMRs. Genes with no connections were dropped. B) Starting with a set of 23 genes near T2D-associated directionally conserved cross-species DMRs, this network was grown by adding genes near species-conserved and mouse-only genome-wide significant DMRs in order to represent one potential regulatory network. Gene colors explained in within-figure legend. See also Figure S4 for the permutation analysis of the enrichment of interactions in Figure 4A.