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. 2014 Oct 28;93(2):167–176. doi: 10.1038/icb.2014.90

Figure 2.

Figure 2

Ackr2 deficiency has no impact on the generation of anti-collagen antibodies in CIA and or on antibody-induced arthritis. (a) Serum levels of anti-collagen mouse IgG1 and IgG2a in arthritic wild-type littermate control (WT) and Ackr2-deficient (Ackr2−/−) DBA/1j mice (n=16) at 35 days after the first collagen immunization. (b) Collagen antibody-induced arthritis (CAIA) was induced in wild-type (WT) and Ackr2-deficient (Ackr2−/−) DBA/1j mice with each animal assessed every 1 to 2 days for clinical symptoms of arthritis. Each point represents the mean±s.e.m. scores of n=5 mice. Significance was determined by two-way repeated measures analysis of variance (ANOVA).