. Author manuscript; available in PMC: 2015 Feb 25.

Published in final edited form as: Taiwan J Ophthalmol. 2011 Dec 1;1(1):12–15. doi: 10.1016/j.tjo.2011.09.001

Table 2. Risk of visual loss for relatives of LHON probands.

	Risk of visual loss
	m.11778G>A	m.14484T>C
Siblings
Brother	25%	28%
Sister	8%	5%

Sister’s children
Nephew	41%	30%
Niece	7%	3%

Maternal first cousins
Male	30%	19%
Female	7%	4%

The recurrence risks for the m.3460G>A mutation have not been determined in a large number of pedigrees. However, these are unlikely to differ significantly from the reported estimates for the m. 11778G>A and m.14484T>C LHON mutations.^3,4