Table 2.

Total (AUC) and incremental (iAUC) areas under the curve for GLP-1 (pmol/L·120 min) following glucose, glutamine and water ingestion in LEAN (n = 8), OB-CON (n = 8) and OB-DIAB (n = 8) subjects.

AUC	LEAN Subjects	OB-CON subjects	OB-DIAB subjects	ANOVA P value
Glucose	3192 ± 431 (0.01)	2550 ± 145 (<0.001)	1846 ± 185 (0.001)*†	0.01
Glutamine	2245 ± 187 (<0.001)	1929 ± 169 (0.05)	1653 ± 207 (0.004)	0.11
Water	1548 ± 146	1396 ± 97	1054 ± 137*	0.04

iAUC	LEAN Subjects	OB-CON subjects	OB-DIAB subjects	ANOVA P value
Glucose	1242 ± 385 (0.008)	1082 ± 102 (<0.001)	746 ± 159 (0.005)	0.37
Glutamine	560 ± 185 (0.01)	344 ± 199 (0.05)	480 ± 170 (0.04)	0.71
Water	−17 ± 89	−219 ± 82	−73 ± 86	0.25

Data are mean ± SE (P vs water, paired t-test). ANOVA P value for comparison between subject groups.

^*P<0.05 vs LEAN subjects (unpaired t-test).

^†P<0.01 vs OB-CON subjects (unpaired t-test).