Table 3. CMR data for study population split by TIMI flow at presentation.
| Whole Cohort | TIMI ≤1 | TIMI >1 | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Nitrite (n=33) | Placebo (n=35) | P value | Nitrite (n=27) | Placebo (n = 30) | P value | Nitrite (n=4) | Placebo (n = 5) | P value | |
| Baseline CMR | |||||||||
| LVEDVi (ml/m2) | 76.13 (71.11-81.14) | 70.58 (65.22-75.94) | 0.13 | 75.69 (69.93-81.44) | 70.33 (64.31-76.34) | 0.19 | 78.01 (51.65-104.40) | 71.99 (54.30-89.68) | 0.58 |
| LVESVi (ml/m2) | 36.16 (32.56-39.75) | 35.71 (30.94-40.48) | 0.88 | 35.16 (31.20-39.12) | 35.41 (30.62-40.20) | 0.94 | 39.90 (18.85-60.94) | 37.37 (12.14-62.80) | 0.84 |
| LVMi (g/m2) | 63.02 (58.65-67.40) | 58.23 (54.67-61.79) | 0.09 | 61.07 (56.27-65.88) | 58.07 (54.44-61.71) | 0.31 | 74.11 (58.19-90.03) | 59.12 (40.75-77.49) | 0.13 |
| LVEF (%) | 52.87 (49.88-55.86) | 50.07 (46.46-53.67) | 0.23 | 53.86 (50.40-57.32) | 50.00 (46.43-53.57) | 0.12 | 49.55 (40.32-58.78) | 50.50 (29.96-71.04) | 0.92 |
| IS (% LV) | 17.10 (14.12-20.08) | 19.55 (16.40-22.70) | 0.25 | 15.31 (12.36-18.27) | 20.08 (16.72-23.43) | 0.03 | 21.43 (9.62-33.23) | 15.86 (0.42-31.30) | 0.40 |
| AAR (% LV) | 34.58 (31.62-37.55) | 33.05 (29.40-36.72) | 0.52 | 33.89 (30.54-37.24) | 33.27 (29.12-37.42) | 0.82 | 35.71 (21.15-50.28) | 31.74 (21.62-41.87) | 0.51 |
| MSI | 0.52 (0.46-0.58) | 0.44 (0.39-0.49) | 0.05 | 0.56 (0.50-0.62) | 0.43 (0.37-0.49) | 0.002 | 0.41 (0.31-0.51) | 0.54 (0.30-0.78) | 0.17 |
| MVO | |||||||||
| No. (%) | 16 (48.5%) | 23 (69.7%) | 0.13 | 10 (37.0%) | 21 (72.4%) | 0.02 | 3 (75.0%) | 1 (25.0%) | 0.14 |
| Amount (g) (median IQR) | 2.98 (0-6.25) | 3.47 (0-4.75) | 0.34 | 1.00 (0.80-5.87) | 4.50 (1-7.50) | 0.003 | 1 (0-8.25) | 1 (0-1) | 0.09 |
| 6 month CMR | (n=29) | (n=33) | (n=25) | (n=29) | (n=2) | (n=4) | |||
| LVEDVi (ml/m2) | 82.13 (74.80-89.46) | 75.62 (69.90-81.34) | 0.15 | 79.27 (72.01-86.54) | 75.37 (69.20-81.53) | 0.40 | 109.94 (−184.6-404.5) | 80.57 (60.05-101.1) | 0.16 |
| LVESVi (ml/m2) | 36.50 (31.48-41.52) | 34.85 (30.53-39.17) | 0.61 | 33.80 (30.08-37.54) | 34.94 (30.16-39.73) | 0.71 | 64.97 (−216.3-346.2) | 37.42 (25.62-49.21) | 0.13 |
| LVMi (g/m2) | 55.67 (51.66-59.68) | 51.20 (48.17-54.24) | 0.07 | 54.21 (50.35-58.07) | 51.09 (47.75-54.44) | 0.21 | 73.36 (−80.60-227.3) | 52.14 (46.98-57.30) | 0.05 |
| LVEF (%) | 55.93 (52.71-59.15) | 54.75 (51.62-57.87) | 0.59 | 57.19 (54.12-60.27) | 54.51 (50.96-58.05) | 0.25 | 42.43 (−61.45-146.30) | 53.51 (43.38-63.65) | 0.18 |
| IS (%) | 11.88 (9.52-14.24) | 13.15 (10.75-15.56) | 0.45 | 10.69 (8.38-13.02) | 13.70 (11.16-16.24) | 0.08 | 16.33 (−9.40-42.06) | 10.59 (0.24-20.93) | 0.32 |
Values shown as mean (95% CI). Abbreviations: LVEDVi, Indexed left ventricle end-diastolic volume; LVESVi, Indexed left ventricle end-systolic volume; LVMi, Indexed left ventricle mass; LVEF, left ventricle ejection fraction; AAR, area at risk; MSI, myocardial salvage index; MVO, microvascular obstruction