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. Author manuscript; available in PMC: 2015 Oct 15.
Published in final edited form as: J Immunol. 2014 Sep 8;193(8):4095–4106. doi: 10.4049/jimmunol.1401192

Figure 4. Neuroglial activation is increased in the absence of IL-1 signaling during WNV encephalitis.

Figure 4

Histological analysis of glial activation in the CNS of WT or IL-1R1−/− mice. Brain tissues from WNV-infected mice were collected on day 8 p.i. Confocal analysis of (A) GFAP (red) and CD3 (green) expression from cerbral cortex and of (C) IBA-1 (red) and CD3 (green) expression from brainstem of WT (left) and IL-1R1−/− mice (right). Quantitative analysis of GFAP (B) and IBA-1 (D) in both WT and IL-1R1−/− mice. Representative images shown are from 4-5 mice per group. Data are from at least 2 experiments in which 10 images were analyzed in each of the mice and presented as mean values ± S.E.M. *p<0.05 Bars, 25 μm.