Table 2. Global deaths for 235 causes in 1990 and 2013 for all ages and both sexes combined and age-standardised death rates.
| All ages deaths (thousands) |
Age-standardised death rate (per 100 000) |
|||||
|---|---|---|---|---|---|---|
| 1990 | 2013 | Median % change | 1990 | 2013 | Median % change | |
| All causes | 47 468·7 (46 771·7 to 48 223·3) | 54 863·8 (53 576·1 to 56 333·6) | 15·6 (12·54 to 19·11) | 1160·5 (1143·2 to 1179·0) | 879·7 (859·9 to 902·2) | −24·2 (−26·20 to −21·96) |
| Communicable, maternal, neonatal, and nutritional diseases | 16 149·4 (15 674·5 to 16 597·6) | 11 809·6 (11 335·5 to 12 283·0) | −26·8 (−29·99 to −24·10) | 289·5 (281·2 to 298·4) | 172·2 (165·2 to 178·8) | −40·5 (−42·98 to −38·35) |
| HIV/AIDS and tuberculosis | 2072·5 (1938·2 to 2246·1) | 2631·2 (2497·3 to 2863·2) | 26·8 (17·08 to 37·92) | 49·3 (46·2 to 53·3) | 38·0 (36·0 to 41·6) | −23·1 (−29·02 to −16·39) |
|
| ||||||
| Tuberculosis | 1786·1 (1666·4 to 1945·4) | 1290·3 (1167·3 to 1406·2) | −27·7 (−34·99 to −20·56) | 43·5 (40·4 to 47·2) | 19·4 (17·6 to 21·2) | −55·3 (−59·67 to −51·01) |
| HIV/AIDS | 286·4 (227·4 to 370·3) | 1341·0 (1257·8 to 1482·6) | 374·2 (262·47 to 490·73) | 5·8 (4·6 to 7·6) | 18·5 (17·4 to 20·5) | 222·0 (145·14 to 303·34) |
| HIV/AIDS resulting in mycobacterial infection | 27·8 (20·5 to 37·4) | 84·0 (67·4 to 104·9) | 205·1 (130·68 to 291·83) | 0·6 (0·4 to 0·8) | 1·2 (0·9 to 1·4) | 105·5 (55·00 to 166·22) |
| HIV/AIDS resulting in other diseases | 258·6 (206·1 to 334·4) | 1257·0 (1178·1 to 1391·1) | 393·2 (276·86-511·66) | 5·3 (4·2 to 6·8) | 17·4 (16·3 to 19·2) | 235·0 (154·55 to 319·43) |
|
| ||||||
| Diarrhoea, lower respiratory infections, and other common infectious diseases | 7880·5 (7468·3 to 8337·2) | 4750·5 (4388·8 to 5029·9) | −39·4 (−45·17 to −35·89) | 143·7 (137·3 to 151·9) | 72·4 (66·7 to 76·5) | −49·4 (−53·54 to −46·75) |
|
| ||||||
| Diarrhoeal diseases | 2578·7 (2412·2 to 2748·9) | 1264·1 (1151·2 to 1383·2) | −51·0 (−55·55 to −46·25) | 47·4 (44·4 to 50·1) | 19·0 (17·4 to 20·8) | −59·8 (−63·54 to −55·96) |
| Intestinal infectious diseases | 259·1 (145·6 to 424·6) | 221·3 (122·6 to 362·6) | −14·3 (−26·08 to −2·75) | 4·3 (2·4 to 7·0) | 3·1 (1·7 to 5·0) | −28·7 (−38·19 to −18·98) |
| Typhoid fever | 180·5 (96·4 to 302·3) | 160·7 (85·9 to 268·0) | −10·8 (−23·70 to 4·24) | 3·0 (1·6 to 5·0) | 2·2 (1·2 to 3·7) | −25·9 (−36·31 to −13·57) |
| Paratyphoid fever | 63·4 (33·6 to 106·7) | 54·3 (29·3 to 92·0) | −14·9 (−30·51 to 9·48) | 1·0 (0·6 to 1·7) | 0·7 (0·4 to 1·3) | −28·0 (−40·99 to −7·97) |
| Other intestinal infectious diseases | 15·3 (13·5 to 17·3) | 6·3 (5·5 to 7·0) | −59·1 (−63·26 to −54·09) | 0·3 (0·2 to 0·3) | 0·1 (0·1 to 0·1) | −66·7 (−70·02 to −62·84) |
| Lower respiratory infections | 3420·7 (3211·6 to 3638·4) | 2652·6 (2368·0 to 2808·1) | −22·2 (−29·71 to −16·32) | 66·8 (63·1 to 71·6) | 41·7 (37·1 to 44·1) | −37·4 (−42·54 to −33·45) |
| Upper respiratory infections | 4·7 (4·0 to 5·6) | 3·9 (3·3 to 4·7) | −16·4 (−33·55 to 4·22) | 0·1 (0·1 to 0·1) | 0·1 (0·1 to 0·1) | −40·8 (−52·40 to −26·16) |
| Otitis media | 4·9 (4·5 to 5·3) | 2·4 (2·3 to 2·6) | −50·8 (−54·22 to −46·41) | 0·1 (0·1 to 0·1) | 0·0 (0·0 to 0·0) | −60·8 (−63·34 to −57·76) |
| Meningitis | 464·4 (405·0 to 559·0) | 303·5 (261·4 to 346·3) | −34·3 (−45·34 to −24·08) | 7·7 (6·8 to 9·0) | 4·3 (3·7 to 4·9) | −43·9 (−52·65 to −36·07) |
| Pneumococcal meningitis | 112·1 (97·7 to 132·6) | 79·1 (67·8 to 91·1) | −29·4 (−39·84 to −16·86) | 1·9 (1·7 to 2·2) | 1·1 (1·0 to 1·3) | −41·7 (−49·60 to −31·37) |
| Haemophilus influenzae type B meningitis | 118·0 (98·2 to 147·0) | 64·4 (53·0 to 76·4) | −45·4 (−54·79 to −33·50) | 1·8 (1·5 to 2·2) | 0·9 (0·7 to 1·1) | −49·7 (−58·21 to −39·32) |
| Meningococcal meningitis | 88·1 (76·1 to 108·0) | 65·7 (55·9 to 75·8) | −24·9 (−38·82 to −12·62) | 1·5 (1·3 to 1·8) | 0·9 (0·8 to 1·1) | −37·3 (−47·55 to −27·80) |
| Other meningitis | 146·1 (128·0 to 174·9) | 94·2 (82·2 to 106·4) | −35·1 (−47·16 to −24·71) | 2·5 (2·2 to 2·9) | 1·3 (1·2 to 1·5) | −45·9 (−54·98 to −37·48) |
| Encephalitis | 92·2 (65·2 to 116·2) | 77·3 (65·4 to 97·0) | −15·2 (−40·15 to 16·01) | 1·6 (1·1 to 1·9) | 1·1 (0·9 to 1·4) | −28·7 (−48·10 to −4·52) |
| Diphtheria | 8·0 (3·9 to 18·8) | 3·3 (1·7 to 6·6) | −57·7 (−85·61 to 12·54) | 0·1 (0·1 to 0·3) | 0·0 (0·0 to 0·1) | −60·8 (−86·70 to 2·82) |
| Whooping cough | 138·2 (52·9 to 300·2) | 60·6 (22·3 to 136·8) | −56·7 (−83·76 to 14·31) | 1·9 (0·7 to 4·2) | 0·8 (0·3 to 1·9) | −58·2 (−84·31 to 10·44) |
| Tetanus | 356·2 (292·9 to 578·6) | 58·9 (39·8 to 77·3) | −82·1 (−92·00 to −76·10) | 5·7 (4·7 to 9·1) | 0·8 (0·6 to 1·1) | −83·9 (−92·72 to −77·84) |
| Measles | 544·5 (304·0 to 867·8) | 95·6 (48·5 to 172·9) | −83·0 (−90·23 to −67·93) | 7·8 (4·3 to 12·4) | 1·3 (0·7 to 2·4) | −83·7 (−90·66 to −69·19) |
| Varicella | 8·9 (7·2 to 11·7) | 7·0 (5·7 to 8·7) | −21·4 (−43·72 to 4·63) | 0·2 (0·2 to 0·3) | 0·1 (0·1 to 0·1) | −45·6 (−61·28 to −27·33) |
|
| ||||||
| Neglected tropical diseases and malaria | 1092·4 (994·1 to 1196·7) | 997·0 (840·5 to 1185·2) | −9·2 (−25·09 to 10·78) | 18·5 (17·0 to 20·2) | 13·9 (11·8 to 16·5) | −24·9 (−37·19 to −9·70) |
|
| ||||||
| Malaria | 888·1 (793·4 to 992·7) | 854·6 (702·9 to 1032·5) | −4·4 (−23·61 to 19·83) | 14·6 (13·2 to 16·2) | 11·9 (9·8 to 14·4) | −18·9 (−34·32 to 0·18) |
| Chagas disease | 12·7 (5·2 to 39·4) | 10·6 (4·2 to 33·0) | −19·3 (−41·12 to 25·58) | 0·3 (0·1 to 1·1) | 0·2 (0·1 to 0·5) | −51·7 (−66·06 to −24·52) |
| Leishmaniasis | 52·2 (44·6 to 60·6) | 62·5 (52·3 to 73·3) | 19·8 (3·56 to 37·74) | 0·9 (0·7 to 1·0) | 0·9 (0·7 to 1·0) | −0·3 (−14·18 to 14·25) |
| Visceral leishmaniasis | 52·2 (44·6 to 60·6) | 62·5 (52·3 to 73·3) | 19·8 (3·56 to 37·74) | 0·9 (0·7 to 1·0) | 0·9 (0·7 to 1·0) | −0·3 (−14·18 to 14·25) |
| African trypanosomiasis | 23·0 (11·4 to 37·7) | 6·9 (3·7 to 10·9) | −69·7 (−73·88 to −64·94) | 0·5 (0·2 to 0·7) | 0·1 (0·1 to 0·1) | −78·9 (−81·76 to −75·54) |
| Schistosomiasis | 17·4 (14·8 to 20·6) | 5·5 (4·9 to 6·2) | −68·2 (−73·56 to −61·68) | 0·4 (0·4 to 0·5) | 0·1 (0·1 to 0·1) | −80·7 (−84·06 to −76·71) |
| Cysticercosis | 0·9 (0·8 to 1·1) | 0·7 (0·5 to 1·0) | −28·6 (−35·23 to −15·09) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | −53·0 (−57·59 to −43·63) |
| Cystic echinococcosis | 4·0 (3·8 to 4·3) | 2·2 (2·1 to 2·4) | −45·0 (−48·34 to −41·22) | 0·1 (0·1 to 0·1) | 0·0 (0·0 to 0·0) | −60·8 (−62·99 to −58·26) |
| Dengue | 8·8 (5·2 to 11·3) | 9·1 (5·6 to 10·8) | −1·3 (−21·69 to 74·08) | 0·1 (0·1 to 0·2) | 0·1 (0·1 to 0·2) | −13·6 (−31·42 to 42·41) |
| Yellow fever | 2·2 (1·9 to 2·5) | 0·5 (0·4 to 0·6) | −77·2 (−80·99 to −72·34) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | −83·3 (−86·08 to −79·71) |
| Rabies | 38·4 (26·7 to 48·7) | 23·5 (17·3 to 28·6) | −38·3 (−53·14 to −24·37) | 0·7 (0·5 to 0·9) | 0·3 (0·2 to 0·4) | −54·0 (−64·09 to −44·23) |
| Intestinal nematode infections | 9·1 (8·1 to 10·2) | 4·5 (4·0 to 5·1) | −50·7 (−56·28 to −43·47) | 0·1 (0·1 to 0·2) | 0·1 (0·1 to 0·1) | −54·7 (−59·66 to −48·46) |
| Ascariasis | 9·1 (8·1 to 10·2) | 4·5 (4·0 to 5·1) | −50·7 (−56·28 to −43·47) | 0·1 (0·1 to 0·2) | 0·1 (0·1 to 0·1) | −54·7 (−59·66 to −48·46) |
| Other neglected tropical diseases | 35·6 (26·4 to 44·2) | 16·3 (13·9 to 19·6) | −54·4 (−64·57 to −36·37) | 0·6 (0·5 to 0·8) | 0·2 (0·2 to 0·3) | −62·3 (−69·58 to −49·75) |
|
| ||||||
| Maternal disorders | 376·6 (344·0 to 408·2) | 293·3 (261·3 to 328·2) | −22·3 (−31·63 to −11·38) | 6·9 (6·3 to 7·5) | 3·9 (3·5 to 4·4) | −43·6 (−50·45 to −35·70) |
|
| ||||||
| Maternal haemorrhage | 71·4 (64·6 to 78·5) | 44·2 (38·3 to 51·0) | −38·1 (−47·24 to −27·03) | 1·3 (1·2 to 1·4) | 0·6 (0·5 to 0·7) | −55·0 (−61·51 to −46·97) |
| Maternal sepsis and other maternal infections | 34·1 (30·5 to 38·0) | 23·8 (20·1 to 28·0) | −30·4 (−42·43 to −15·10) | 0·6 (0·6 to 0·7) | 0·3 (0·3 to 0·4) | −50·0 (−58·40 to −39·00) |
| Maternal hypertensive disorders | 36·6 (33·3 to 39·9) | 29·3 (25·7 to 33·5) | −20·0 (−30·89 to −7·22) | 0·7 (0·6 to 0·7) | 0·4 (0·3 to 0·4) | −41·3 (−49·14 to −32·20) |
| Obstructed labour | 29·3 (26·3 to 32·7) | 18·8 (16·3 to 21·8) | −35·9 (−45·56 to −23·86) | 0·5 (0·5 to 0·6) | 0·2 (0·2 to 0·3) | −53·4 (−60·20 to −44·45) |
| Complications of abortion | 50·0 (45·8 to 54·8) | 43·7 (38·3 to 49·9) | −12·6 (−24·72 to 2·00) | 0·9 (0·9 to 1·0) | 0·6 (0·5 to 0·7) | −37·5 (−46·15 to −26·71) |
| Indirect maternal deaths | 40·1 (35·5 to 44·4) | 31·1 (26·8 to 35·8) | −22·7 (−34·25 to −7·62) | 0·7 (0·6 to 0·8) | 0·4 (0·4 to 0·5) | −43·4 (−51·81 to −32·38) |
| Late maternal deaths | 44·9 (36·4 to 53·2) | 43·5 (35·7 to 52·4) | −1·8 (−26·81 to 21·95) | 0·8 (0·7 to 1·0) | 0·6 (0·5 to 0·7) | −28·4 (−46·61 to −11·67) |
| Maternal deaths aggravated by HIV/AIDS | 0·8 (0·5 to 1·1) | 2·1 (1·3 to 2·9) | 161·7 (128·02 to 202·66) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | 94·1 (69·26 to 124·47) |
| Other maternal disorders | 68·6 (58·4 to 80·4) | 56·2 (48·7 to 64·4) | −18·2 (−31·79 to −0·04) | 1·3 (1·1 to 1·5) | 0·7 (0·6 to 0·9) | −40·8 (−50·36 to −27·88) |
|
| ||||||
| Neonatal disorders | 3433·3 (3225·7 to 3586·1) | 2048·0 (1934·7 to 2160·3) | −40·3 (−43·96 to −36·30) | 46·9 (44·1 to 49·0) | 27·6 (26·1 to 29·1) | −41·1 (−44·71 to −37·13) |
|
| ||||||
| Preterm birth complications | 1570·5 (1285·0 to 1803·5) | 742·4 (591·3 to 910·8) | −52·9 (−58·70 to −45·50) | 21·4 (17·5 to 24·6) | 10·0 (8·0 to 12·3) | −53·5 (−59·23 to −46·20) |
| Neonatal encephalopathy (birth asphyxia/trauma) | 874·1 (688·5 to 1055·4) | 643·8 (515·0 to 760·5) | −26·1 (−38·29 to −11·35) | 11·9 (9·4 to 14·4) | 8·7 (6·9 to 10·3) | −27·1 (−39·06 to −12·49) |
| Neonatal sepsis and other neonatal infections | 346·4 (195·7 to 484·0) | 366·0 (233·2 to 510·8) | 6·1 (−15·94 to 38·04) | 4·7 (2·7 to 6·6) | 4·9 (3·1 to 6·9) | 4·6 (−17·13 to 35·99) |
| Haemolytic disease and other neonatal jaundice | 64·8 (39·5 to 96·3) | 19·6 (13·0 to 29·7) | −70·0 (−79·78 to −50·43) | 0·9 (0·5 to 1·3) | 0·3 (0·2 to 0·4) | −70·6 (−80·17 to −51·17) |
| Other neonatal disorders | 577·6 (457·5 to 756·0) | 276·2 (219·6 to 350·7) | −52·3 (−62·41 to −36·77) | 7·9 (6·3 to 10·3) | 3·7 (3·0 to 4·7) | −53·0 (−63·01 to −37·68) |
|
| ||||||
| Nutritional deficiencies | 757·7 (641·5 to 934·4) | 681·1 (533·5 to 795·5) | −9·7 (−22·87 to 1·86) | 14·7 (12·4 to 18·2) | 10·4 (8·2 to 12·2) | −28·6 (−38·77 to −20·45) |
|
| ||||||
| Protein-energy malnutrition | 507·9 (394·3 to 648·5) | 468·8 (350·0 to 560·9) | −7·3 (−22·92 to 7·51) | 9·2 (7·1 to 11·8) | 7·1 (5·3 to 8·5) | −22·5 (−34·54 to −11·34) |
| Iodine deficiency | 2·1 (1·4 to 3·4) | 2·7 (1·5 to 4·7) | 24·5 (−29·82 to 137·21) | 0·0 (0·0 to 0·1) | 0·0 (0·0 to 0·1) | −7·9 (−47·13 to 80·62) |
| Iron-deficiency anemia | 213·4 (143·5 to 309·3) | 183·4 (122·0 to 259·2) | −13·8 (−32·36 to 5·33) | 4·6 (3·3 to 6·6) | 2·8 (1·9 to 4·0) | −38·8 (−50·36 to −26·57) |
| Other nutritional deficiencies | 34·3 (23·8 to 56·1) | 26·2 (17·0 to 41·2) | −22·5 (−42·66 to −4·64) | 0·8 (0·5 to 1·3) | 0·4 (0·3 to 0·7) | −45·4 (−56·40 to −33·85) |
|
| ||||||
| Other communicable, maternal, neonatal, and nutritional diseases | 536·5 (433·0 to 674·9) | 408·4 (342·1 to 488·3) | −23·8 (−33·94 to −11·53) | 9·4 (7·9 to 11·4) | 5·9 (5·0 to 7·0) | −37·4 (−44·55 to −28·28) |
|
| ||||||
| Sexually transmitted diseases excluding HIV | 257·6 (154·7 to 396·4) | 142·0 (87·6 to 213·9) | −44·5 (−55·96 to −32·77) | 3·8 (2·4 to 5·7) | 1·9 (1·2 to 2·9) | −48·4 (−58·54 to −37·36) |
| Syphilis | 250·6 (147·4 to 389·1) | 136·8 (82·4 to 208·9) | −45·1 (−56·56 to −33·02) | 3·6 (2·2 to 5·5) | 1·9 (1·1 to 2·9) | −48·0 (−58·61 to −36·83) |
| Chlamydial infection | 1·5 (1·1 to 1·9) | 1·1 (0·9 to 1·4) | −23·0 (−42·59 to 0·03) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | −51·1 (−64·66 to −34·62) |
| Gonococcal infection | 3·2 (2·5 to 3·8) | 2·3 (2·0 to 2·9) | −26·6 (−41·91 to −6·75) | 0·1 (0·1 to 0·1) | 0·0 (0·0 to 0·0) | −54·0 (−64·57 to −39·74) |
| Other sexually transmitted diseases | 2·4 (1·9 to 2·8) | 1·7 (1·5 to 2·1) | −27·3 (−42·08 to −10·71) | 0·1 (0·0 to 0·1) | 0·0 (0·0 to 0·0) | −53·2 (−63·49 to −40·60) |
| Hepatitis | 162·0 (152·8 to 171·4) | 136·7 (123·7 to 163·2) | −16·8 (−25·24 to 2·96) | 3·3 (3·1 to 3·5) | 2·0 (1·8 to 2·4) | −39·6 (−45·37 to −25·80) |
| Hepatitis A | 22·6 (7·9 to 40·2) | 14·9 (5·0 to 27·7) | −36·3 (−50·41 to −2·45) | 0·3 (0·1 to 0·6) | 0·2 (0·1 to 0·4) | −41·9 (−54·39 to −12·04) |
| Hepatitis B | 85·0 (65·1 to 104·0) | 68·6 (52·0 to 86·6) | −19·7 (−28·94 to −4·23) | 1·9 (1·5 to 2·2) | 1·1 (0·8 to 1·3) | −44·6 (−50·38 to −35·37) |
| Hepatitis C | 2·3 (0·5 to 5·3) | 3·5 (0·7 to 8·2) | 51·0 (24·40 to 86·56) | 0·1 (0·0 to 0·1) | 0·1 (0·0 to 0·1) | −4·2 (−20·86 to 17·67) |
| Hepatitis E | 52·1 (39·0 to 67·2) | 49·7 (36·1 to 67·5) | −6·1 (−17·83 to 20·41) | 1·0 (0·7 to 1·3) | 0·7 (0·5 to 1·0) | −30·8 (−39·35 to −11·37) |
| Other infectious diseases | 116·9 (94·0 to 144·3) | 129·8 (89·6 to 164·9) | 11·3 (−21·67 to 45·00) | 2·4 (1·9 to 3·0) | 2·0 (1·4 to 2·5) | −17·7 (−42·92 to 7·31) |
|
| ||||||
| Non-communicable diseases | 26 993·5 (26 298·1 to 27 639·1) | 38 267·2 (37 202·2 to 39 417·6) | 41·7 (36·86 to 47·00) | 782·5 (765·5 to 798·2) | 637·5 (620·4 to 655·7) | −18·6 (−21·08 to −15·78) |
| Neoplasms | 5659·7 (5440·4 to 5826·6) | 8235·7 (7941·4 to 8538·9) | 45·6 (39·82 to 51·55) | 157·0 (151·3 to 161·5) | 133·8 (128·9 to 138·6) | −14·7 (−17·91 to −11·49) |
|
| ||||||
| Oesophageal cancer | 313·1 (275·0 to 351·5) | 440·2 (389·2 to 516·8) | 39·9 (26·42 to 56·36) | 8·8 (7·8 to 9·9) | 7·2 (6·3 to 8·4) | −19·3 (−27·13 to −9·94) |
| Stomach cancer | 763·4 (725·6 to 803·2) | 841·0 (791·6 to 894·1) | 10·1 (3·94 to 17·43) | 21·7 (20·6 to 22·9) | 13·8 (13·0 to 14·7) | −36·3 (−39·82 to −32·14) |
| Liver cancer | 510·1 (474·9 to 543·1) | 818·0 (763·7 to 879·0) | 60·3 (46·21 to 75·28) | 13·7 (12·7 to 14·5) | 13·0 (12·1 to 13·9) | −5·0 (−13·01 to 3·61) |
| Liver cancer secondary to hepatitis B | 198·4 (181·7 to 215·4) | 300·0 (272·0 to 329·2) | 51·6 (33·51 to 72·02) | 5·1 (4·7 to 5·5) | 4·6 (4·2 to 5·1) | −9·1 (−19·63 to 2·69) |
| Liver cancer secondary to hepatitis C | 87·4 (79·5 to 94·7) | 342·5 (317·1 to 375·3) | 290·8 (251·46 to 342·52) | 2·4 (2·2 to 2·6) | 5·5 (5·1 to 6·0) | 125·4 (103·82 to 154·85) |
| Liver cancer secondary to alcohol use | 122·8 (113·8 to 132·5) | 92·2 (84·8 to 100·3) | −25·2 (−31·20 to −17·09) | 3·5 (3·2 to 3·7) | 1·5 (1·4 to 1·6) | −56·4 (−59·87 to −51·82) |
| Other liver cancer | 101·5 (92·8 to 110·0) | 83·3 (75·1 to 92·2) | −17·5 (−28·57 to −7·02) | 2·6 (2·4 to 2·9) | 1·3 (1·2 to 1·4) | −50·5 (−56·97 to −44·23) |
| Larynx cancer | 76·2 (62·7 to 88·1) | 87·6 (74·3 to 106·2) | 14·2 (7·25 to 27·55) | 2·1 (1·7 to 2·4) | 1·4 (1·2 to 1·7) | −33·4 (−37·26 to −26·29) |
| Tracheal, bronchus, and lung cancer | 1050·0 (1010·6 to 1078·2) | 1639·6 (1565·6 to 1706·0) | 56·5 (47·83 to 62·84) | 29·6 (28·5 to 30·4) | 27·0 (25·7 to 28·1) | −8·7 (−13·62 to −5·16) |
| Breast cancer | 327·3 (289·2 to 366·8) | 471·0 (412·0 to 514·2) | 44·2 (35·01 to 51·82) | 9·0 (7·9 to 10·1) | 7·4 (6·4 to 8·1) | −17·5 (−23·42 to −13·38) |
| Cervical cancer | 196·3 (162·9 to 212·4) | 235·7 (201·9 to 257·9) | 20·1 (10·74 to 30·15) | 5·2 (4·3 to 5·6) | 3·6 (3·1 to 4·0) | −30·1 (−35·55 to −24·13) |
| Uterine cancer | 45·6 (36·6 to 55·6) | 67·7 (53·6 to 79·0) | 48·6 (30·64 to 64·39) | 1·3 (1·0 to 1·6) | 1·1 (0·9 to 1·3) | −15·0 (−24·61 to −6·58) |
| Prostate cancer | 157·1 (124·0 to 193·1) | 292·7 (242·2 to 373·9) | 82·8 (71·77 to 109·02) | 5·1 (4·0 to 6·3) | 5·2 (4·3 to 6·6) | −1·0 (−7·17 to 13·05) |
| Colon and rectum cancer | 490·2 (476·1 to 504·5) | 771·1 (741·5 to 799·2) | 57·4 (51·89 to 62·64) | 14·5 (14·1 to 14·9) | 12·8 (12·4 to 13·3) | −11·1 (−14·40 to −8·17) |
| Lip and oral cavity cancer | 83·9 (74·0 to 96·2) | 135·0 (115·3 to 154·3) | 59·7 (46·91 to 78·39) | 2·3 (2·0 to 2·6) | 2·1 (1·8 to 2·5) | −7·9 (−14·96 to 2·32) |
| Nasopharynx cancer | 53·7 (47·7 to 63·5) | 60·5 (54·0 to 69·5) | 12·7 (1·19 to 24·74) | 1·4 (1·2 to 1·6) | 0·9 (0·8 to 1·1) | −32·5 (−39·31 to −25·55) |
| Other pharynx cancer | 48·9 (43·7 to 53·5) | 78·6 (67·0 to 86·3) | 60·9 (43·26 to 76·41) | 1·3 (1·2 to 1·4) | 1·2 (1·0 to 1·3) | −7·1 (−16·97 to 2·04) |
| Gallbladder and biliary tract cancer | 115·4 (100·6 to 130·4) | 139·5 (120·0 to 155·0) | 22·1 (6·85 to 32·36) | 3·4 (3·0 to 3·9) | 2·3 (2·0 to 2·6) | −31·2 (−39·96 to −25·22) |
| Pancreatic cancer | 186·4 (181·3 to 191·8) | 352·4 (339·4 to 364·8) | 89·0 (82·43 to 95·46) | 5·4 (5·3 to 5·6) | 5·9 (5·6 to 6·1) | 7·4 (3·63 to 11·04) |
| Malignant skin melanoma | 38·7 (30·1 to 50·9) | 56·9 (43·9 to 75·7) | 47·6 (31·54 to 57·81) | 1·1 (0·8 to 1·4) | 0·9 (0·7 to 1·2) | −14·1 (−23·86 to −8·06) |
| Non-melanoma skin cancer | 25·0 (20·2 to 30·0) | 39·2 (32·8 to 48·7) | 55·0 (43·30 to 76·59) | 0·8 (0·6 to 0·9) | 0·7 (0·6 to 0·8) | −12·9 (−20·00 to −0·93) |
| Ovarian cancer | 98·9 (93·1 to 106·1) | 157·8 (147·5 to 169·5) | 59·6 (50·81 to 68·88) | 2·7 (2·6 to 2·9) | 2·5 (2·3 to 2·7) | −7·8 (−12·97 to −2·56) |
| Testicular cancer | 7·0 (5·4 to 8·2) | 8·3 (6·3 to 10·4) | 18·4 (8·86 to 35·42) | 0·2 (0·1 to 0·2) | 0·1 (0·1 to 0·1) | −23·0 (−28·60 to −11·08) |
| Kidney cancer | 77·9 (73·8 to 83·0) | 133·8 (126·0 to 141·1) | 71·8 (63·06 to 81·02) | 2·1 (2·0 to 2·3) | 2·2 (2·0 to 2·3) | 1·6 (−3·95 to 8·11) |
| Bladder cancer | 130·8 (116·6 to 140·9) | 173·9 (156·8 to 192·5) | 32·2 (27·35 to 43·06) | 4·0 (3·5 to 4·3) | 3·0 (2·7 to 3·3) | −25·6 (−28·36 to −20·14) |
| Brain and nervous system cancers | 136·0 (116·6 to 155·2) | 203·9 (169·5 to 234·8) | 50·4 (34·04 to 60·33) | 3·3 (2·8 to 3·8) | 3·1 (2·6 to 3·6) | −4·6 (−13·99 to 0·96) |
| Thyroid cancer | 23·8 (20·3 to 26·1) | 33·7 (29·6 to 38·2) | 41·1 (29·80 to 59·27) | 0·7 (0·6 to 0·8) | 0·6 (0·5 to 0·6) | −19·6 (−25·50 to −9·09) |
| Mesothelioma | 17·0 (15·2 to 20·3) | 33·7 (29·4 to 38·7) | 100·5 (69·94 to 115·47) | 0·5 (0·4 to 0·6) | 0·5 (0·5 to 0·6) | 16·2 (−2·42 to 24·92) |
| Hodgkin lymphoma | 33·6 (24·1 to 38·0) | 24·2 (22·0 to 31·6) | −33·0 (−40·41 to 15·35) | 0·8 (0·5 to 0·8) | 0·4 (0·3 to 0·5) | −54·9 (−58·93 to −24·34) |
| Non-Hodgkin lymphoma | 133·6 (116·3 to 158·0) | 225·5 (186·3 to 245·8) | 72·0 (41·51 to 84·35) | 3·5 (3·1 to 4·2) | 3·6 (2·9 to 3·9) | 6·1 (−14·56 to 13·42) |
| Multiple myeloma | 45·3 (37·4 to 57·4) | 79·4 (65·3 to 94·2) | 77·1 (53·64 to 90·08) | 1·3 (1·1 to 1·7) | 1·3 (1·1 to 1·6) | 0·4 (−13·32 to 8·27) |
| Leukaemia | 223·8 (215·1 to 234·2) | 265·1 (253·9 to 275·8) | 18·7 (11·69 to 24·19) | 5·2 (5·0 to 5·4) | 4·1 (3·9 to 4·3) | −20·0 (−24·12 to −16·68) |
| Other neoplasms | 250·6 (231·8 to 305·2) | 369·6 (328·0 to 400·1) | 51·3 (15·57 to 62·10) | 6·2 (5·8 to 7·3) | 5·8 (5·2 to 6·3) | −4·2 (−23·44 to 3·32) |
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| Cardiovascular diseases | 12 279·6 (11 776·6 to 12 764·1) | 17 297·5 (16 520·2 to 18 071·9) | 40·8 (36·17 to 46·36) | 375·5 (360·5 to 389·1) | 293·2 (280·4 to 306·1) | −22·0 (−24·50 to −19·07) |
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| Rheumatic heart disease | 373·5 (302·5 to 464·6) | 275·1 (222·6 to 353·9) | −26·5 (−33·64 to −17·20) | 9·8 (7·9 to 12·2) | 4·4 (3·5 to 5·6) | −55·4 (−59·47 to −50·11) |
| Ischaemic heart disease | 5737·5 (5254·9 to 6148·6) | 8139·9 (7322·9 to 8758·5) | 41·7 (35·96 to 48·44) | 177·3 (161·8 to 190·2) | 137·8 (123·9 to 148·2) | −22·3 (−25·48 to −18·68) |
| Cerebrovascular disease | 4584·8 (4162·1 to 4968·1) | 6446·9 (5963·0 to 7155·2) | 40·2 (34·43 to 49·56) | 141·6 (128·5 to 153·9) | 110·1 (101·8 to 122·2) | −22·5 (−25·56 to −17·30) |
| Ischaemic stroke | 2182·9 (1923·3 to 2430·9) | 3272·9 (2812·7 to 3592·6) | 50·2 (41·02 to 59·27) | 71·3 (63·0 to 79·3) | 57·3 (49·3 to 62·9) | −19·6 (−24·52 to −14·97) |
| Haemorrhagic stroke | 2401·9 (2109·4 to 2669·1) | 3174·0 (2885·7 to 3719·7) | 30·7 (22·23 to 49·07) | 70·3 (61·2 to 77·9) | 52·8 (48·0 to 62·3) | −25·9 (−30·64 to −14·73) |
| Hypertensive heart disease | 622·1 (525·7 to 783·9) | 1068·6 (849·8 to 1242·2) | 74·1 (47·34 to 93·73) | 19·3 (16·4 to 24·4) | 18·2 (14·5 to 21·3) | −4·5 (−18·86 to 6·41) |
| Cardiomyopathy and myocarditis | 293·9 (243·5 to 346·3) | 443·3 (370·1 to 512·0) | 51·4 (37·27 to 61·45) | 8·2 (6·9 to 9·6) | 7·1 (6·0 to 8·3) | −12·6 (−19·98 to −7·68) |
| Atrial fibrillation and flutter | 28·9 (26·0 to 32·4) | 112·2 (97·7 to 126·7) | 288·1 (246·32 to 335·03) | 1·0 (0·9 to 1·1) | 2·0 (1·8 to 2·3) | 100·0 (77·55 to 124·90) |
| Aortic aneurysm | 99·6 (82·4 to 118·5) | 151·5 (124·2 to 180·0) | 52·1 (43·75 to 60·91) | 3·0 (2·5 to 3·6) | 2·6 (2·1 to 3·1) | −15·3 (−20·06 to −10·50) |
| Peripheral vascular disease | 15·9 (14·4 to 17·5) | 40·5 (35·5 to 44·9) | 155·3 (126·51 to 178·39) | 0·5 (0·5 to 0·6) | 0·7 (0·6 to 0·8) | 34·1 (18·77 to 46·62) |
| Endocarditis | 45·1 (35·6 to 58·6) | 65·0 (48·6 to 79·4) | 46·3 (23·88 to 65·52) | 1·2 (1·0 to 1·6) | 1·0 (0·8 to 1·3) | −12·7 (−25·81 to −2·80) |
| Other cardiovascular and circulatory diseases | 478·3 (403·9 to 546·4) | 554·6 (499·1 to 654·2) | 15·2 (9·38 to 32·52) | 13·6 (11·5 to 15·5) | 9·3 (8·3 to 10·8) | −32·2 (−35·44 to −22·40) |
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| ||||||
| Chronic respiratory diseases | 3490·2 (3280·4 to 3795·3) | 4267·5 (3996·3 to 4694·2) | 21·9 (14·95 to 31·48) | 104·5 (98·5 to 113·3) | 73·0 (68·4 to 80·2) | −30·4 (−34·19 to −25·05) |
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| Chronic obstructive pulmonary disease | 2421·3 (2151·3 to 2632·4) | 2931·2 (2626·3 to 3215·8) | 21·0 (12·70 to 31·26) | 74·8 (66·8 to 81·2) | 50·7 (45·4 to 55·6) | −32·3 (−36·75 to −26·54) |
| Pneumoconiosis | 251·2 (184·0 to 317·8) | 259·7 (201·7 to 331·2) | 1·9 (−15·21 to 40·27) | 7·2 (5·3 to 9·0) | 4·3 (3·3 to 5·5) | −40·5 (−50·81 to −19·84) |
| Silicosis | 55·4 (36·7 to 77·1) | 46·3 (32·1 to 64·8) | −16·0 (−32·85 to 6·14) | 1·6 (1·0 to 2·2) | 0·8 (0·5 to 1·1) | −50·7 (−61·18 to −38·06) |
| Asbestosis | 21·0 (13·9 to 30·4) | 24·1 (17·5 to 32·3) | 14·2 (−10·20 to 54·87) | 0·6 (0·4 to 0·9) | 0·4 (0·3 to 0·5) | −32·6 (−47·35 to −9·61) |
| Coal workers pneumoconiosis | 28·9 (18·2 to 43·9) | 25·2 (19·0 to 35·6) | −13·7 (−30·65 to 23·06) | 0·8 (0·5 to 1·2) | 0·4 (0·3 to 0·6) | −50·2 (−60·26 to −29·13) |
| Other pneumoconiosis | 145·9 (100·3 to 189·2) | 164·1 (123·1 to 213·6) | 10·9 (−13·48 to 61·23) | 4·2 (2·9 to 5·5) | 2·7 (2·0 to 3·6) | −35·3 (−50·19 to −6·77) |
| Asthma | 504·3 (399·7 to 731·8) | 489·0 (397·7 to 676·8) | −2·9 (−24·58 to 19·21) | 13·7 (10·8 to 20·4) | 8·0 (6·5 to 11·1) | −41·5 (−55·17 to −28·01) |
| Interstitial lung disease and pulmonary sarcoidosis | 217·6 (128·7 to 299·4) | 471·5 (372·3 to 606·8) | 114·1 (53·25 to 214·86) | 6·6 (3·9 to 8·9) | 8·0 (6·3 to 10·3) | 20·1 (−11·89 to 74·20) |
| Other chronic respiratory diseases | 95·8 (78·3 to 113·8) | 116·1 (99·2 to 136·9) | 21·2 (7·78 to 40·66) | 2·2 (1·8 to 2·7) | 1·9 (1·6 to 2·3) | −15·1 (−24·22 to −3·39) |
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| Cirrhosis of the liver | 838·0 (807·0 to 866·7) | 1221·1 (1170·3 to 1284·3) | 45·6 (38·47 to 54·52) | 21·8 (20·9 to 22·5) | 18·8 (18·0 to 19·7) | −13·7 (−17·75 to −8·49) |
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| Cirrhosis of the liver secondary to hepatitis B | 233·9 (220·8 to 250·0) | 317·4 (292·3 to 344·6) | 35·6 (22·66 to 49·58) | 6·1 (5·7 to 6·5) | 4·9 (4·5 to 5·3) | −19·3 (−26·86 to −11·11) |
| Cirrhosis of the liver secondary to hepatitis C | 213·1 (200·4 to 226·7) | 357·8 (334·3 to 386·1) | 67·3 (54·60 to 83·86) | 5·7 (5·4 to 6·0) | 5·6 (5·2 to 6·0) | −2·4 (−9·58 to 7·48) |
| Cirrhosis of the liver secondary to alcohol use | 292·2 (276·5 to 307·1) | 383·8 (356·2 to 414·7) | 31·2 (20·27 to 43·97) | 7·8 (7·4 to 8·2) | 5·9 (5·5 to 6·4) | −24·1 (−30·24 to −16·92) |
| Other cirrhosis of the liver | 98·8 (92·1 to 106·0) | 162·1 (145·5 to 182·9) | 63·5 (47·65 to 86·21) | 2·2 (2·0 to 2·3) | 2·4 (2·1 to 2·7) | 9·3 (−1·52 to 24·19) |
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| Digestive diseases | 1053·2 (958·6 to 1131·2) | 1168·3 (1064·4 to 1275·5) | 10·4 (2·11 to 22·38) | 28·4 (25·8 to 30·5) | 19·0 (17·4 to 20·7) | −335 (−38·30 to −26·51) |
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| Peptic ulcer disease | 326·9 (288·8 to 388·7) | 301·4 (249·8 to 350·5) | −7·6 (−21·26 to 5·52) | 9·1 (8·0 to 10·7) | 4·9 (4·1 to 5·7) | −45·8 (−53·37 to −38·53) |
| Gastritis and duodenitis | 54·2 (32·1 to 76·3) | 59·5 (42·2 to 90·1) | 5·8 (−13·46 to 50·38) | 1·4 (0·8 to 2·0) | 1·0 (0·7 to 1·5) | −35·1 (−46·54 to −6·86) |
| Appendicitis | 87·5 (70·8 to 105·9) | 71·9 (51·4 to 89·5) | −17·8 (−34·66 to 2·68) | 2·0 (1·6 to 2·4) | 1·1 (0·8 to 1·4) | −45·7 (−56·37 to −33·27) |
| Paralytic ileus and intestinal obstruction | 178·0 (116·3 to 228·5) | 235·7 (175·6 to 327·0) | 29·4 (11·32 to 68·61) | 4·7 (3·1 to 6·1) | 3·8 (2·8 to 5·3) | −20·3 (−31·07 to 1·80) |
| Inguinal, femoral, and abdominal hernia | 50·5 (33·2 to 61·2) | 32·5 (25·6 to 48·8) | −41·8 (−49·26 to −4·88) | 1·4 (0·9 to 1·7) | 0·5 (0·4 to 0·8) | −64·8 (−69·29 to −44·12) |
| Inflammatory bowel disease | 54·9 (40·4 to 67·2) | 51·2 (42·4 to 69·7) | −8·7 (−17·41 to 13·01) | 1·4 (1·0 to 1·6) | 0·8 (0·7 to 1·1) | −41·8 (−47·30 to −25·30) |
| Vascular intestinal disorders | 52·6 (34·7 to 78·4) | 79·5 (51·9 to 113·3) | 51·8 (36·03 to 67·16) | 1·6 (1·1 to 2·4) | 1·4 (0·9 to 1·9) | −16·3 (−24·49 to −8·10) |
| Gallbladder and biliary diseases | 80·5 (68·9 to 94·1) | 105·9 (89·1 to 122·3) | 32·2 (18·76 to 43·46) | 2·4 (2·0 to 2·8) | 1·8 (1·5 to 2·1) | −24·5 (−31·76 to −18·21) |
| Pancreatitis | 83·0 (59·2 to 111·3) | 122·6 (85·9 to 152·3) | 49·1 (16·02 to 76·94) | 2·1 (1·5 to 2·9) | 1·9 (1·3 to 2·4) | −10·2 (−29·33 to 5·74) |
| Other digestive diseases | 85·2 (73·3 to 99·5) | 108·0 (90·4 to 124·2) | 27·1 (14·25 to 39·04) | 2·3 (2·0 to 2·6) | 1·8 (1·5 to 2·0) | −21·9 (−29·04 to −15·13) |
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| Neurological disorders | 1017·5 (965·0 to 1072·3) | 1976·8 (1875·0 to 2080·7) | 94·0 (83·99 to 106·61) | 34·2 (32·3 to 36·1) | 35·0 (33·2 to 36·9) | 2·3 (−3·27 to 9·08) |
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| Alzheimer’s disease and other dementias | 795·8 (747·9 to 844·3) | 1655·1 (1563·5 to 1765·3) | 107·2 (94·94 to 124·00) | 28·9 (27·1 to 30·7) | 29·9 (28·2 to 31·9) | 3·2 (−3·01 to 11·61) |
| Parkinson’s disease | 43·7 (38·3 to 55·1) | 102·5 (79·3 to 112·6) | 139·8 (77·36 to 156·99) | 1·5 (1·3 to 1·9) | 1·8 (1·4 to 2·0) | 28·2 (−6·42 to 37·83) |
| Epilepsy | 111·0 (95·5 to 129·9) | 115·8 (93·7 to 132·0) | 4·7 (−12·05 to 24·00) | 2·2 (1·9 to 2·5) | 1·7 (1·3 to 1·9) | −22·4 (−33·73 to −10·21) |
| Multiple sclerosis | 12·4 (9·2 to 19·0) | 19·8 (12·8 to 25·5) | 64·8 (3·60 to 87·09) | 0·3 (0·2 to 0·5) | 0·3 (0·2 to 0·4) | −1·1 (−38·78 to 11·91) |
| Other neurological disorders | 54·6 (47·1 to 60·8) | 83·7 (71·8 to 90·8) | 54·2 (37·88 to 60·72) | 1·4 (1·2 to 1·5) | 1·3 (1·1 to 1·4) | −3·6 (−10·27 to 0·43) |
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| Mental and substance use disorders | 188·3 (157·2 to 242·3) | 282·4 (233·9 to 329·3) | 51·5 (32·26 to 63·84) | 4·3 (3·6 to 5·7) | 4·0 (3·3 to 4·7) | −5·7 (−18·55 to 2·10) |
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| Schizophrenia | 22·8 (14·7 to 28·3) | 16·0 (13·7 to 22·8) | −35·5 (−46·52 to 29·94) | 0·6 (0·4 to 0·7) | 0·2 (0·2 to 0·3) | −59·7 (−66·47 to −20·07) |
| Alcohol use disorders | 111·9 (84·0 to 165·3) | 139·2 (90·2 to 178·5) | 28·2 (1·78 to 35·66) | 2·7 (2·0 to 3·9) | 2·0 (1·3 to 2·6) | −22·0 (−38·53 to −17·54) |
| Drug use disorders | 53·2 (47·8 to 64·1) | 126·6 (110·8 to 135·5) | 140·4 (101·60 to 159·88) | 1·1 (1·0 to 1·3) | 1·8 (1·6 to 1·9) | 63·0 (36·10 to 74·81) |
| Opioid use disorders | 18·0 (16·5 to 22·2) | 50·7 (43·4 to 54·4) | 187·3 (134·80 to 210·24) | 0·4 (0·3 to 0·5) | 0·7 (0·6 to 0·8) | 92·7 (56·69 to 107·16) |
| Cocaine use disorders | 2·4 (2·2 to 2·9) | 4·3 (3·9 to 4·7) | 77·2 (49·11 to 102·26) | 0·1 (0·0 to 0·1) | 0·1 (0·1 to 0·1) | 20·9 (1·97 to 36·34) |
| Amphetamine use disorders | 2·1 (1·9 to 2·5) | 3·8 (3·4 to 4·1) | 80·4 (52·49 to 106·70) | 0·0 (0·0 to 0·1) | 0·1 (0·0 to 0·1) | 23·2 (4·70 to 40·49) |
| Other drug use disorders | 30·7 (26·1 to 37·3) | 67·7 (59·5 to 72·8) | 122·8 (86·51 to 146·32) | 0·6 (0·6 to 0·8) | 1·0 (0·8 to 1·0) | 51·6 (26·34 to 65·39) |
| Eating disorders | 0·4 (0·3 to 0·4) | 0·6 (0·5 to 0·7) | 60·4 (41·17 to 84·68) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | 13·5 (−0·42 to 30·16) |
| Anorexia nervosa | 0·4 (0·3 to 0·4) | 0·6 (0·5 to 0·7) | 60·4 (41·17 to 84·68) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | 13·5 (−0·42 to 30·16) |
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| Diabetes, urogenital, blood, and endocrine diseases | 1569·4 (1456·7 to 1709·2) | 2955·0 (2764·0 to 3171·1) | 88·9 (76·44 to 99·49) | 42·2 (39·5 to 44·7) | 48·3 (45·1 to 51·4) | 14·4 (9·53 to 20·14) |
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| Diabetes mellitus | 684·3 (653·2 to 711·5) | 1299·4 (1234·5 to 1374·8) | 89·7 (81·77 to 99·94) | 19·8 (18·9 to 20·6) | 21·6 (20·6 to 22·9) | 9·0 (4·59 to 14·69) |
| Acute glomerulonephritis | 23·6 (13·7 to 33·4) | 18·8 (14·3 to 22·8) | −21·4 (−36·96 to 14·96) | 0·5 (0·3 to 0·8) | 0·3 (0·2 to 0·3) | −45·8 (−55·70 to −21·57) |
| Chronic kidney disease | 408·6 (363·8 to 433·4) | 956·2 (812·9 to 1034·5) | 134·6 (115·70 to 150·20) | 11·6 (10·4 to 12·3) | 15·8 (13·5 to 17·1) | 36·9 (25·43 to 46·11) |
| Chronic kidney disease due to diabetes mellitus | 46·3 (34·8 to 54·8) | 173·1 (139·3 to 208·8) | 274·1 (243·06 to 309·05) | 1·4 (1·0 to 1·6) | 2·9 (2·3 to 3·5) | 106·5 (89·67 to 127·74) |
| Chronic kidney disease due to hypertension | 120·0 (91·6 to 144·8) | 275·7 (196·9 to 336·5) | 130·6 (106·28 to 151·38) | 3·6 (2·8 to 4·4) | 4·6 (3·3 to 5·6) | 29·4 (15·20 to 40·43) |
| Chronic kidney disease due to glomerulonephritis | 99·0 (84·5 to 114·7) | 116·3 (92·9 to 144·0) | 16·9 (1·69 to 35·32) | 2·5 (2·1 to 2·9) | 1·8 (1·5 to 2·3) | −26·8 (−35·84 to −15·66) |
| Chronic kidney diseases due to other causes | 143·3 (115·3 to 168·0) | 391·2 (297·0 to 452·3) | 175·3 (140·05 to 202·16) | 4·1 (3·3 to 4·8) | 6·5 (4·9 to 7·5) | 58·8 (37·59 to 74·71) |
| Urinary diseases and male infertility due to other causes | 151·4 (129·1 to 161·1) | 245·8 (205·5 to 264·7) | 62·8 (49·74 to 72·37) | 4·3 (3·7 to 4·6) | 4·1 (3·4 to 4·4) | −3·7 (−12·86 to 1·66) |
| Interstitial nephritis and urinary tract infections | 109·9 (92·9 to 118·1) | 175·5 (144·6 to 192·0) | 58·9 (48·57 to 74·08) | 3·1 (2·7 to 3·4) | 2·9 (2·4 to 3·2) | −6·3 (−14·36 to 2·19) |
| Urolithiasis | 15·1 (11·1 to 18·7) | 14·7 (12·4 to 20·1) | −5·9 (−16·02 to 44·87) | 0·4 (0·3 to 0·5) | 0·2 (0·2 to 0·3) | −45·3 (−50·97 to −14·32) |
| Other urinary diseases | 26·3 (21·9 to 35·0) | 55·5 (40·4 to 66·5) | 122·4 (69·54 to 151·57) | 0·7 (0·6 to 1·0) | 0·9 (0·7 to 1·1) | 32·5 (2·75 to 50·04) |
| Gynaecological diseases | 5·3 (3·9 to 7·0) | 3·4 (2·9 to 4·8) | −36·7 (−47·76 to −14·33) | 0·1 (0·1 to 0·2) | 0·1 (0·0 to 0·1) | −59·5 (−67·15 to −45·56) |
| Uterine fibroids | 1·2 (0·9 to 1·7) | 0·9 (0·7 to 1·2) | −29·7 (−43·96 to −6·20) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | −57·8 (−66·54 to −43·72) |
| Polycystic ovarian syndrome | 0·2 (0·1 to 0·3) | 0·1 (0·1 to 0·2) | −56·2 (−63·48 to −29·90) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | −68·5 (−73·81 to −49·56) |
| Endometriosis | 0·5 (0·4 to 0·6) | 0·2 (0·2 to 0·4) | −54·7 (−62·11 to −29·37) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | −68·9 (−74·05 to −51·25) |
| Genital prolapse | 0·9 (0·7 to 1·2) | 0·6 (0·5 to 0·9) | −29·9 (−44·02 to −8·28) | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | −55·7 (−65·45 to −42·31) |
| Other gynaecological diseases | 2·5 (1·8 to 3·2) | 1·6 (1·3 to 2·2) | −37·4 (−48·19 to −15·38) | 0·1 (0·0 to 0·1) | 0·0 (0·0 to 0·0) | −59·7 (−67·23 to −46·18) |
| Haemoglobinopathies and haemolytic anaemias | 182·7 (91·5 to 302·5) | 240·4 (106·0 to 456·1) | 20·6 (−1·35 to 92·91) | 3·1 (1·6 to 5·0) | 3·4 (1·5 to 6·3) | 0·4 (−19·05 to 51·95) |
| Thalassaemias | 36·2 (21·2 to 49·4) | 24·8 (16·9 to 32·1) | −36·4 (−46·90 to 14·05) | 0·6 (0·3 to 0·8) | 0·3 (0·2 to 0·4) | −43·7 (−52·63 to −2·83) |
| Sickle cell disorders | 112·9 (39·4 to 222·6) | 176·2 (56·3 to 385·7) | 45·3 (14·30 to 131·19) | 1·8 (0·6 to 3·4) | 2·4 (0·8 to 5·3) | 28·8 (1·53 to 94·35) |
| G6PD deficiency | 3·4 (2·0 to 4·6) | 4·1 (2·6 to 5·6) | 12·7 (−7·12 to 91·90) | 0·1 (0·0 to 0·1) | 0·1 (0·0 to 0·1) | −8·2 (−23·19 to 45·12) |
| Other haemoglobinopathies and haemolytic anaemias | 30·3 (19·8 to 38·6) | 35·4 (24·3 to 44·9) | 15·1 (3·42 to 46·66) | 0·8 (0·5 to 1·0) | 0·6 (0·4 to 0·7) | −25·8 (−31·66 to −9·80) |
| Endocrine, metabolic, blood, and immune disorders | 113·5 (90·6 to 134·4) | 191·0 (150·5 to 218·5) | 69·5 (49·11 to 85·62) | 2·7 (2·2 to 3·2) | 3·0 (2·4 to 3·4) | 11·6 (0·55 to 20·87) |
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| Musculoskeletal disorders | 65·9 (55·0 to 73·4) | 116·3 (100·4 to 137·7) | 77·1 (54·42 to 105·22) | 1·7 (1·5 to 1·9) | 1·9 (1·6 to 2·2) | 8·5 (−4·62 to 23·48) |
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| Rheumatoid arthritis | 27·8 (23·8 to 31·7) | 38·1 (33·0 to 46·9) | 35·6 (16·43 to 64·74) | 0·8 (0·7 to 0·9) | 0·6 (0·5 to 0·8) | −20·5 (−31·22 to −4·53) |
| Other musculoskeletal disorders | 38·1 (30·3 to 44·1) | 78·2 (65·2 to 90·3) | 107·2 (76·94 to 145·59) | 0·9 (0·8 to 1·1) | 1·2 (1·0 to 1·4) | 32·7 (14·17 to 51·37) |
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| Other non-communicable diseases | 831·7 (690·7 to 1061·0) | 746·6 (674·1 to 846·2) | −7·6 (−25·31 to 4·05) | 12·9 (10·9 to 16·1) | 10·5 (9·5 to 11·9) | −164 (−30·83 to −7·20) |
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| Congenital anomalies | 750·6 (611·8 to 969·7) | 632·1 (561·3 to 730·3) | −13·5 (−30·40 to −0·80) | 11·0 (9·0 to 14·1) | 8·7 (7·7 to 10·0) | −18·9 (−34·07 to −7·54) |
| Neural tube defects | 151·3 (109·1 to 256·3) | 68·9 (40·9 to 124·4) | −54·8 (−65·35 to −42·39) | 2·1 (1·5 to 3·6) | 0·9 (0·6 to 1·7) | −56·6 (−66·71 to −44·61) |
| Congenital heart anomalies | 366·2 (293·0 to 485·2) | 323·4 (288·3 to 372·6) | −9·8 (−29·83 to 7·37) | 5·4 (4·4 to 7·0) | 4·5 (4·0 to 5·1) | −15·8 (−33·64 to −0·61) |
| Orofacial clefts | 7·6 (4·2 to 11·5) | 3·3 (1·9 to 5·2) | −57·8 (−68·83 to −33·93) | 0·1 (0·1 to 0·2) | 0·0 (0·0 to 0·1) | −58·5 (−69·40 to −35·04) |
| Down’s syndrome | 42·5 (16·4 to 73·0) | 36·4 (20·4 to 52·4) | −12·9 (−39·13 to 40·14) | 0·7 (0·3 to 1·1) | 0·5 (0·3 to 0·7) | −22·6 (−45·11 to 19·89) |
| Chromosomal unbalanced rearrangements | 19·1 (8·5 to 41·2) | 17·3 (10·6 to 26·8) | 5·5 (−40·18 to 35·89) | 0·3 (0·1 to 0·6) | 0·2 (0·1 to 0·4) | −3·0 (−43·13 to 25·13) |
| Other congenital anomalies | 163·9 (119·9 to 301·9) | 182·8 (150·2 to 261·9) | 18·0 (−16·45 to 40·74) | 2·4 (1·8 to 4·4) | 2·5 (2·1 to 3·6) | 8·5 (−20·90 to 29·30) |
| Skin and subcutaneous diseases | 59·1 (54·1 to 63·1) | 99·4 (89·9 to 107·3) | 68·3 (51·36 to 86·44) | 1·6 (1·5 to 1·7) | 1·6 (1·5 to 1·8) | 2·5 (−7·66 to 10·83) |
| Cellulitis | 27·0 (19·0 to 34·1) | 29·5 (22·5 to 39·3) | 8·0 (−5·23 to 30·03) | 0·7 (0·5 to 0·8) | 0·5 (0·4 to 0·6) | −29·8 (−38·47 to −16·25) |
| Pyoderma | 16·7 (11·6 to 23·1) | 37·7 (30·2 to 42·9) | 129·9 (71·83 to 186·99) | 0·4 (0·3 to 0·6) | 0·6 (0·5 to 0·7) | 44·0 (14·02 to 75·43) |
| Decubitus ulcer | 13·7 (11·5 to 16·9) | 28·5 (24·4 to 33·0) | 109·6 (82·53 to 132·42) | 0·5 (0·4 to 0·6) | 0·5 (0·4 to 0·6) | 8·3 (−4·81 to 19·09) |
| Other skin and subcutaneous diseases | 1·7 (1·2 to 2·2) | 3·8 (3·0 to 4·9) | 138·4 (74·18 to 201·77) | 0·0 (0·0 to 0·1) | 0·1 (0·0 to 0·1) | 35·9 (4·37 to 69·36) |
| Sudden infant death syndrome | 22·0 (12·7 to 40·2) | 15·1 (9·6 to 21·4) | −29·5 (−54·51 to −4·22) | 0·3 (0·2 to 0·6) | 0·2 (0·1 to 0·3) | −31·0 (−55·52 to −6·34) |
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| Injuries | 4325·8 (4095·7 to 4524·0) | 4786·9 (4507·9 to 5072·8) | 10·4 (4·23 to 18·04) | 88·5 (84·5 to 93·0) | 70·0 (65·9 to 74·2) | −21·0 (−25·27 to −15·85) |
| Transport injuries | 1150·0 (1092·9 to 1253·9) | 1482·7 (1364·8 to 1588·8) | 29·3 (17·11 to 38·66) | 23·2 (22·1 to 25·1) | 21·2 (19·5 to 22·7) | −8·4 (−16·54 to −2·02) |
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| Road injuries | 1058·4 (1005·0 to 1167·2) | 1395·8 (1286·1 to 1492·7) | 32·4 (19·21 to 41·84) | 21·3 (20·3 to 23·4) | 20·0 (18·4 to 21·3) | −6·1 (−15·12 to 0·28) |
| Pedestrian road injuries | 389·7 (339·6 to 472·0) | 543·8 (452·0 to 629·1) | 40·2 (17·55 to 58·63) | 8·0 (7·0 to 9·6) | 8·0 (6·7 to 9·2) | 0·1 (−15·84 to 12·51) |
| Cyclist road injuries | 68·6 (58·5 to 83·3) | 90·6 (74·2 to 106·6) | 32·0 (13·51 to 51·06) | 1·4 (1·2 to 1·7) | 1·3 (1·1 to 1·6) | −7·5 (−20·14 to 5·51) |
| Motorcyclist road injuries | 202·0 (169·3 to 236·4) | 248·5 (200·9 to 294·4) | 22·8 (7·72 to 40·45) | 3·9 (3·2 to 4·5) | 3·4 (2·8 to 4·0) | −12·2 (−22·77 to 0·56) |
| Motor vehicle road injuries | 364·4 (324·4 to 409·1) | 492·7 (431·0 to 555·1) | 35·5 (24·24 to 46·49) | 7·3 (6·5 to 8·2) | 6·9 (6·1 to 7·8) | −4·9 (−12·90 to 2·69) |
| Other road injuries | 33·8 (21·9 to 44·1) | 20·2 (14·4 to 25·5) | −40·7 (−54·01 to −7·44) | 0·7 (0·4 to 0·9) | 0·3 (0·2 to 0·4) | −57·3 (−67·23 to −34·33) |
| Other transport injuries | 91·6 (77·4 to 102·0) | 86·9 (72·0 to 97·2) | −5·3 (−18·27 to 10·72) | 1·9 (1·6 to 2·1) | 1·2 (1·0 to 1·4) | −33·6 (−42·61 to −22·72) |
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| Unintentional injuries other than transport injuries | 2017·2 (1848·6 to 2165·7) | 2006·7 (1857·1 to 2183·1) | −1·0 (−8·96 to 10·95) | 40·8 (38·2 to 43·8) | 30·4 (28·0 to 32·9) | −25·7 (−31·89 to −18·23) |
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| Falls | 340·5 (311·7 to 411·5) | 556·4 (448·5 to 610·7) | 66·7 (21·25 to 82·98) | 9·0 (8·2 to 10·8) | 9·1 (7·3 to 9·9) | 3·4 (−23·97 to 11·61) |
| Drowning | 544·9 (409·2 to 635·8) | 368·1 (311·0 to 515·4) | −35·0 (−43·35 to 17·98) | 9·4 (7·2 to 10·8) | 5·2 (4·4 to 7·3) | −46·3 (−52·33 to −6·00) |
| Fire, heat, and hot substances | 299·6 (262·7 to 352·9) | 237·5 (199·3 to 282·9) | −21·2 (−33·96 to −1·98) | 5·9 (5·2 to 7·0) | 3·5 (2·9 to 4·1) | −41·9 (−50·85 to −29·74) |
| Poisonings | 120·2 (104·1 to 168·5) | 98·0 (70·2 to 110·8) | −12·7 (−44·83 to −0·08) | 2·4 (2·1 to 3·3) | 1·4 (1·0 to 1·6) | −36·0 (−58·97 to −27·57) |
| Exposure to mechanical forces | 232·7 (186·3 to 273·9) | 196·8 (177·9 to 244·6) | −15·6 (−31·65 to 18·68) | 4·1 (3·4 to 4·8) | 2·8 (2·5 to 3·5) | −32·6 (−43·48 to −9·05) |
| Unintentional firearm injuries | 51·4 (44·5 to 60·0) | 47·3 (41·0 to 55·7) | −7·6 (−26·30 to 13·15) | 1·0 (0·9 to 1·2) | 0·7 (0·6 to 0·8) | −32·8 (−46·94 to −18·02) |
| Unintentional suffocation | 84·0 (26·9 to 124·6) | 37·6 (29·1 to 80·7) | −58·3 (−74·65 to 90·29) | 1·2 (0·4 to 1·8) | 0·5 (0·4 to 1·1) | −59·7 (−75·13 to 71·19) |
| Other exposure to mechanical forces | 97·2 (88·8 to 119·9) | 111·9 (95·5 to 122·4) | 16·6 (−13·64 to 30·93) | 1·9 (1·7 to 2·3) | 1·6 (1·4 to 1·7) | −14·7 (−36·50 to −5·26) |
| Adverse effects of medical treatment | 93·5 (77·2 to 110·2) | 141·7 (107·5 to 165·9) | 53·2 (27·88 to 73·38) | 2·1 (1·8 to 2·6) | 2·2 (1·7 to 2·6) | 4·6 (−11·30 to 16·34) |
| Animal contact | 95·5 (59·8 to 126·6) | 79·6 (62·3 to 138·7) | −22·0 (−35·47 to 34·57) | 1·9 (1·2 to 2·5) | 1·2 (0·9 to 2·0) | −43·0 (−52·23 to −2·49) |
| Venomous animal contact | 76·3 (47·5 to 104·7) | 57·2 (44·1 to 102·5) | −30·1 (−43·14 to 28·05) | 1·5 (0·9 to 2·0) | 0·8 (0·6 to 1·5) | −49·3 (−58·49 to −6·80) |
| Non-venomous animal contact | 19·2 (11·5 to 26·3) | 22·4 (16·4 to 36·8) | 11·2 (−9·33 to 73·85) | 0·4 (0·2 to 0·5) | 0·3 (0·2 to 0·6) | −16·9 (−31·27 to 25·18) |
| Foreign body | 142·2 (99·5 to 211·6) | 165·7 (114·8 to 219·1) | 16·2 (−10·22 to 45·91) | 2·9 (2·1 to 4·3) | 2·6 (1·8 to 3·4) | −10·2 (−29·81 to 5·96) |
| Pulmonary aspiration and foreign body in airway | 139·8 (97·2 to 209·7) | 162·1 (109·8 to 214·7) | 15·5 (−11·10 to 45·78) | 2·9 (2·0 to 4·2) | 2·5 (1·7 to 3·4) | −10·6 (−30·35 to 5·87) |
| Foreign body in other body part | 2·5 (1·6 to 3·5) | 3·6 (2·7 to 5·4) | 51·5 (−3·11 to 84·33) | 0·1 (0·0 to 0·1) | 0·1 (0·0 to 0·1) | 6·8 (−25·59 to 31·38) |
| Other unintentional injuries | 148·1 (119·9 to 162·8) | 162·8 (143·9 to 180·3) | 9·3 (−4·23 to 33·11) | 3·1 (2·5 to 3·4) | 2·4 (2·1 to 2·7) | −21·1 (−30·53 to −4·99) |
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| Self-harm and interpersonal violence | 1052·8 (929·3 to 1152·0) | 1247·1 (1067·2 to 1390·9) | 18·2 (8·38 to 29·00) | 22·4 (19·8 to 24·6) | 17·8 (15·3 to 19·8) | −20·8 (−27·32 to −13·83) |
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| Self-harm | 712·0 (630·6 to 784·7) | 842·4 (718·1 to 939·0) | 17·8 (6·04 to 32·20) | 15·8 (13·9 to 17·3) | 12·2 (10·4 to 13·6) | −23·1 (−30·45 to −13·97) |
| Interpersonal violence | 340·7 (253·9 to 415·1) | 404·7 (298·7 to 496·6) | 18·4 (10·24 to 29·34) | 6·6 (4·9 to 8·1) | 5·6 (4·1 to 6·9) | −16·0 (−21·65 to −8·41) |
| Assault by firearm | 127·6 (89·9 to 165·1) | 180·4 (120·5 to 231·3) | 41·3 (26·05 to 55·53) | 2·5 (1·7 to 3·2) | 2·5 (1·6 to 3·2) | 0·0 (−10·58 to 10·11) |
| Assault by sharp object | 94·0 (65·1 to 127·8) | 114·3 (77·1 to 163·2) | 21·0 (6·27 to 40·68) | 1·8 (1·3 to 2·5) | 1·6 (1·1 to 2·2) | −15·2 (−25·63 to −1·29) |
| Assault by other means | 119·1 (84·4 to 142·9) | 110·0 (78·7 to 142·1) | −8·5 (−16·48 to 7·97) | 2·3 (1·6 to 2·8) | 1·5 (1·1 to 2·0) | −33·9 (−39·44 to −22·31) |
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| Forces of nature, war, and legal intervention | 105·8 (77·2 to 170·7) | 50·4 (34·4 to 88·8) | −53·1 (−58·41 to −46·15) | 2·2 (1·5 to 3·6) | 0·7 (0·5 to 1·3) | −66·2 (−70·18 to −61·18) |
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| Exposure to forces of nature | 33·4 (19·4 to 63·5) | 19·2 (13·5 to 32·0) | −43·9 (−58·70 to −6·92) | 0·7 (0·4 to 1·4) | 0·3 (0·2 to 0·5) | −60·4 (−71·50 to −33·98) |
| Collective violence and legal intervention | 72·4 (54·7 to 106·5) | 31·2 (20·3 to 57·0) | −57·9 (−66·76 to −45·85) | 1·5 (1·1 to 2·2) | 0·5 (0·3 to 0·8) | −69·3 (−75·76 to −61·23) |
Data in parentheses are 95% uncertainty intervals.