Skip to main content
. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: J Neurochem. 2013 Nov 13;128(5):752–763. doi: 10.1111/jnc.12492

Figure 2. Astroglial Cx43 hemichannels increases their opening upon HIV infection.

Figure 2

Etd uptake rate for human primary astrocytes exposed to HIVADA for 7 days is shown. Control cells have minimal Etd uptake (Cont). HIV infection resulted in significant increase in Etd uptake (*p<0.005). Addition of Cx43 HC blockers, lanthanum ions (La3+, 200 μM), Cx43E2 antibody (1:500 dilution) or peptide gap26 (200 μM) abolished the increase of Etd uptake induced by HIV infection. In contrast, blockers of Panx1 HCs, such as Probenecid (Prob, 500 μM), and 10panx1 (200 μM) did not alter the Etd uptake induced by the virus. The scrambled peptide for gap26 and 10panx1 (scrb, 200 μM) did not affect Etd uptake induced by the virus. Each value corresponds to the mean ± SD, (* represents significance of p<0.005 as compared to control conditions (cont), # represent significant difference as compared to HIV infection alone, n=4).