Table 3. Neutralization activities of KNH1144 antisera in different formats.
Neutralization titers for the KNH1144 sera were measured in the CF2-based assays. V3 and CD4i activity was assessed in a post-CD4 format and MPER titers were measured in post-CD4/CCR5 assays. Results are expressed as ID50s or IC50s corresponding to dilutions or concentrations in μg/ml. The titers are color coded for sera and Abs as described for Tables 1 and 2, respectively.
Serum | Immunogen (Protein only) | KNH1144 | KNH1144 SOS |
---|---|---|---|
CF2 post-CD4 | CF2 post-CD4/CCR5 | ||
5-1 | KNH1144 gp120 | 500 | <10 |
6-4 | KNH1144 SOSIP | 12,000 | <10 |
2F5 (μg/ml) | 0.1 | 0.1 | |
b12 (μg/ml) | >10 | >10 |