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. Author manuscript; available in PMC: 2015 Feb 26.
Published in final edited form as: Pediatr Dev Pathol. 2014 Sep 10;17(6):441–449. doi: 10.2350/14-06-1505-OA.1

Table 2.

Final backward-selected Cox model tests: age at diagnosis and covariates INSS, MYCN status, DNA index, and grade of neuroblastic differentiation

Table 2a-1. EFS for Patients with Low MKI
Variable (n = 2273)a DF P value Hazard ratio 95% CI on hazard ratio
Age (<60 months vs ≥60 months) 1 <0.0001 2.458 (1.926, 3.137)
INSS stage (not stage 4 vs stage 4) 1 <0.0001 2.772 (2.249, 3.416)
DNA index (hyperdiploid vs diploid) 1 <0.0001 1.555 (1.265, 1.911)
Table 2a-2. OS for patients with low MKI
Variable (n = 2273)b DF P value Hazard ratio 95% CI on hazard ratio
Age (<60 months vs ≥60 months) 1 <0.0001 3.189 (2.360, 4.310)
INSS stage (not stage 4 vs stage 4) 1 <0.0001 7.566 (5.313, 10.774)
MYCN status (not amplified vs amplified) 1 0.0118 1.766 (1.135, 2.749)
DNA index (hyperdiploid vs diploid) 1 <0.0001 1.846 (1.392, 2.450)
Table 2b-1. EFS for patients with intermediate MKI
Variable (n = 1009)a DF P value Hazard ratio 95% CI on hazard ratio
Age (<18 months vs ≥18 months) 1 <0.0001 2.218 (1.647, 2.986)
INSS stage (not stage 4 vs stage 4) 1 <0.0001 1.982 (1.484, 2.647)
MYCN status (not amplified vs amplified) 1 0.0349 1.351 (1.022, 1.787)
DNA index (hyperdiploid vs diploid) 1 0.0146 1.356 (1.062, 1.732)
Table 2b-2. OS for patients with intermediate MKI
Variable (n = 1009)b DF P value Hazard ratio 95% CI on hazard ratio
Age (<18 months vs ≥18 months) 1 <0.0001 3.188 (2.083, 4.877)
INSS stage (not stage 4 vs stage 4) 1 <0.0001 3.196 (2.108, 4.846)
MYCN status (not amplified vs amplified) 1 <0.0001 2.002 (1.466, 2.733)
DNA index (hyperdiploid vs diploid) 1 0.0260 1.396 (1.041, 1.873)
Table 2c-1. EFS for patients with high MKI
Variable (n = 809)a DF P value Hazard ratio 95% CI on hazard ratio
INSS stage (not stage 4 vs stage 4) 1 <0.0001 2.281 (1.699, 3.061)
DNA index (hyperdiploid vs diploid) 1 0.0015 1.411 (1.142, 1.745)
Table 2c-2. OS for patients with high MKI
Variable (n = 809)b DF P value Hazard ratio 95% CI on hazard ratio
INSS stage (not stage 4 vs stage 4) 1 <0.0001 2.210 (1.578, 3.095)
MYCN status (not amplified vs amplified) 1 0.0011 1.605 (1.207, 2.135)
DNA index (hyperdiploid vs diploid) 1 0.0053 1.421 (1.110, 1.819)
a,b

Variables tested and not statistically significant for EFS: MYCN status and grade; for OS: grade.

INSS indicates International Neuroblastoma Staging System; EFS, event-free survival; OS, overall survival; DF, degrees of freedom; CI, confidence interval.

a,b

Variables tested and not statistically significant: grade.

INSS indicates International Neuroblastoma Staging System; EFS, event-free survival; OS, overall survival; DF, degrees of freedom; CI, confidence interval.

a,b

Variables tested and not statistically significant for EFS: grade, MYCN status, and age; for OS: age and grade.

INSS indicates International Neuroblastoma Staging System; EFS, event-free survival; OS, overall survival; DF, degrees of freedom; CI, confidence interval.