Table 2.
Final backward-selected Cox model tests: age at diagnosis and covariates INSS, MYCN status, DNA index, and grade of neuroblastic differentiation
| Table 2a-1. EFS for Patients with Low MKI
| ||||
|---|---|---|---|---|
| Variable (n = 2273)a | DF | P value | Hazard ratio | 95% CI on hazard ratio |
| Age (<60 months vs ≥60 months) | 1 | <0.0001 | 2.458 | (1.926, 3.137) |
| INSS stage (not stage 4 vs stage 4) | 1 | <0.0001 | 2.772 | (2.249, 3.416) |
| DNA index (hyperdiploid vs diploid) | 1 | <0.0001 | 1.555 | (1.265, 1.911) |
| Table 2a-2. OS for patients with low MKI
| ||||
|---|---|---|---|---|
| Variable (n = 2273)b | DF | P value | Hazard ratio | 95% CI on hazard ratio |
| Age (<60 months vs ≥60 months) | 1 | <0.0001 | 3.189 | (2.360, 4.310) |
| INSS stage (not stage 4 vs stage 4) | 1 | <0.0001 | 7.566 | (5.313, 10.774) |
| MYCN status (not amplified vs amplified) | 1 | 0.0118 | 1.766 | (1.135, 2.749) |
| DNA index (hyperdiploid vs diploid) | 1 | <0.0001 | 1.846 | (1.392, 2.450) |
| Table 2b-1. EFS for patients with intermediate MKI
| ||||
|---|---|---|---|---|
| Variable (n = 1009)a | DF | P value | Hazard ratio | 95% CI on hazard ratio |
| Age (<18 months vs ≥18 months) | 1 | <0.0001 | 2.218 | (1.647, 2.986) |
| INSS stage (not stage 4 vs stage 4) | 1 | <0.0001 | 1.982 | (1.484, 2.647) |
| MYCN status (not amplified vs amplified) | 1 | 0.0349 | 1.351 | (1.022, 1.787) |
| DNA index (hyperdiploid vs diploid) | 1 | 0.0146 | 1.356 | (1.062, 1.732) |
| Table 2b-2. OS for patients with intermediate MKI
| ||||
|---|---|---|---|---|
| Variable (n = 1009)b | DF | P value | Hazard ratio | 95% CI on hazard ratio |
| Age (<18 months vs ≥18 months) | 1 | <0.0001 | 3.188 | (2.083, 4.877) |
| INSS stage (not stage 4 vs stage 4) | 1 | <0.0001 | 3.196 | (2.108, 4.846) |
| MYCN status (not amplified vs amplified) | 1 | <0.0001 | 2.002 | (1.466, 2.733) |
| DNA index (hyperdiploid vs diploid) | 1 | 0.0260 | 1.396 | (1.041, 1.873) |
| Table 2c-1. EFS for patients with high MKI
| ||||
|---|---|---|---|---|
| Variable (n = 809)a | DF | P value | Hazard ratio | 95% CI on hazard ratio |
| INSS stage (not stage 4 vs stage 4) | 1 | <0.0001 | 2.281 | (1.699, 3.061) |
| DNA index (hyperdiploid vs diploid) | 1 | 0.0015 | 1.411 | (1.142, 1.745) |
| Table 2c-2. OS for patients with high MKI
| ||||
|---|---|---|---|---|
| Variable (n = 809)b | DF | P value | Hazard ratio | 95% CI on hazard ratio |
| INSS stage (not stage 4 vs stage 4) | 1 | <0.0001 | 2.210 | (1.578, 3.095) |
| MYCN status (not amplified vs amplified) | 1 | 0.0011 | 1.605 | (1.207, 2.135) |
| DNA index (hyperdiploid vs diploid) | 1 | 0.0053 | 1.421 | (1.110, 1.819) |
Variables tested and not statistically significant for EFS: MYCN status and grade; for OS: grade.
INSS indicates International Neuroblastoma Staging System; EFS, event-free survival; OS, overall survival; DF, degrees of freedom; CI, confidence interval.
Variables tested and not statistically significant: grade.
INSS indicates International Neuroblastoma Staging System; EFS, event-free survival; OS, overall survival; DF, degrees of freedom; CI, confidence interval.
Variables tested and not statistically significant for EFS: grade, MYCN status, and age; for OS: age and grade.
INSS indicates International Neuroblastoma Staging System; EFS, event-free survival; OS, overall survival; DF, degrees of freedom; CI, confidence interval.