TABLE 3.

Kinetics of emergence of AZT resistance mutations in viruses carrying D67N and/or K219Q/E^a

Passage	AZT concn (μM)	RD24.1D67N		RD24.2D67N/K219E		RD25D67N/K219Q		RD26D67N/K219Q
		Days	Mutation(s)	Days	Mutation(s)	Days	Mutation(s)	Days	Mutation(s)
1	0.03	6	ND	8	ND	6	ND	7	ND
2	0.06	13	ND	15	ND	12	ND	12	ND
3	0.12	21		26		19		19	K70K/R
4	0.24	30		35	K219E/G	28		27	K70R/K
5	0.48	38		43	K219E/G	36	K70K/R	33	K70R
6	1	48		50	K219E/G	43	K70R	40	K70R
7	3	60	K70R	62	K219E/G	51	K70R	49	K70R
8	10	72	K70R	74	K70R, K219G	60	K70R	ND

^aSee Table 2, footnote a.