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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Trends Biochem Sci. 2015 Feb 6;40(3):149–156. doi: 10.1016/j.tibs.2015.01.001

Fig. 4. Mst1/2 regulation by Rassf1.

Fig. 4

Mechanistic models of Mst1/2 activation by Rassf1. A. Rassf1 can activate Mst1 and Mst2 is by preventing dephosphorylation by PP2A. B. Rassf1 can activate Mst2 by releasing it from its inhibitory complex with Raf-1. C. Rassf1 can activate Mst2 by preventing its degradation. D. Rassf1 can activate Mst2 by promoting its interaction with its substrate, Lats. Pointed arrowheads indicate activation while blunted ends indicate inhibition.