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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Immunol. 2015 Jan 30;194(5):2319–2329. doi: 10.4049/jimmunol.1402675

Figure 2.

Figure 2

Intranasal immunization with C. trachomatis confers protection against secondary challenge. Groups of 4 C57BL/6 mice were intranasally infected with C. trachomatis. Four weeks later, these mice and naïve mice were rechallenged (A) intranasally or (B) transcervically. Three and six days after rechallenge, tissues were harvested and bacterial burden was determined by quantitative PCR. (C) Goups of 5–19 C57BL/6 mice were intranasally immunized with indicated doses of C. trachomatis. Four weeks after immunization, these mice and naïve mice were challenged in the genital tract. Five days after genital challenge, bacterial burden was determined by quantitative PCR. The data are representative of 3 independent experiments.*: p ≤ 0.05. **: p ≤ 0.01.