Table 1. Baseline Characteristics (n=504).
| Variable | Total Cohort (n=504) |
Detectable cTnI (n=302) |
Undetectable cTnI (n=202) |
p-value |
|---|---|---|---|---|
| Age [years] | 68 ± 10 | 69 ± 11 | 66 ± 10 | 0.01 |
| Male (%) | 63.1 | 67.2 | 56.9 | 0.02 |
| Diabetes (%) | 36.5 | 43.1 | 26.5 | 0.0001 |
| Coronary Artery Disease (%) |
78.0 | 83.3 | 70.0 | 0.0006 |
| Hypertension (%) | 76.4 | 79.7 | 71.6 | 0.04 |
| eGFR [mL/min/1.73 m2] | 74.8 ± 26.2 | 69.3 ± 27.5 | 83.3 ± 21.7 | <.0001 |
| Ever Smoker (%) | 70.2 | 68.5 | 72.8 | 0.3 |
| BMI [kg/m2] | 29 ± 6 | 29 ± 7 | 30 ± 7 | 0.1 |
| Beta-Blocker (%) | 63.3 | 61.3 | 66.3 | 0.3 |
| ACEI / ARB (%) | 68.3 | 65.9 | 71.8 | 0.2 |
| Loop Diuretic (%) | 63.9 | 67.2 | 58.9 | 0.06 |
| Left ventricular ejection fraction [%] |
40 [27, 55] | 35 [25, 50] | 45 [35, 55] | <.0001 |
| NT-proBNP [pg/mL] | 1057 [400, 2715] |
1787 [798, 4720] |
531 [197, 1110] |
<.0001 |
| hs-cTnT [ng/L] | 21.2 [12.3, 40.9] |
32.7 [20.3, 75.2] |
12.5 [8.6, 18.1] |
<.0001 |
Abbreviations: eGFR: estimated glomerular filtration rate, MDRD; BMI: body mass index; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker; NT-proBNP: amino terminus - pro B-type natriuretic peptide; cTnI: cardiac troponin I measured by standard assay; hs-cTnT: cardiac troponin T measured by a highly sensitive assay; and DASI: Duke Activity Status Index.
Continuous values are expressed mean ± standard deviation or median [interquartile range].
For comparison between cTnI levels ≥ or < 0.01 ng/mL, P-values calculated via Student’s T-test or Wilcoxon for continuous variables and Fisher’s Exact Test for categorical variables.