Table 1.
Summary of findings
| J774.16 macrophage like | BMDM | Peritoneal macrophages | ||
|---|---|---|---|---|
| Fungal Control | ++ | ++ | + | |
| ATP Levels | ↓ | ↓↓ | ↓↓ | |
| PCD pathways | ||||
| LDH release | Yes | No | Yes | |
| Annexin V binding | Yes | N.D.2 | Yes | |
| Activation of: | ||||
| Caspases | −8 | −1, −3, −8 | −3 | |
| RIP | Yes | No | N.D.1 | |
| AIF | Yes | Yes | N.D.1 | |
| PARP | No | No | N.D.1 | |
| Release of cytochrome c | No | Yes | N.D.1 | |
| Predicted PCD activated | Necrosis | Apoptosis | Apoptosis/Necrosis | |
| Gene expression | Stress pathways activated | |||
| Mitochondrial characteristics | ||||
| Depolarization | ++ | + | ++ | |
| Morphology | Fragmented | Unchanged | Fragmented | |
| ROS Production | No | No | Yes | |
| Mitochondrial derived ROS | No | No | No | |
| NO-dependence | Yes | N.D.2 | Yes | |
| Protein translation | ↓ | N.D.2 | ↑ | |
N.D.1 not performed due to technical limitations
N.D.2 not pertinent for conclusions of study