Skip to main content
. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):294–307. doi: 10.1097/MPG.0000000000000597

Figure 1. Symbiotic Bacterial Induction of sIgA Via Dendritic Cells.

Figure 1

Dendritic cells sample gut bacteria, which stimulates the formation of local sIgA by plasma cells. This sIgA is distributed along the length of the gut but not systemically. This allows the immune system to block antigenic stimulation at the epithelial surface and preserve systemic reactivity should the bacterium pass the epithelial barrier.

Adapted from Hooper et al. Science 2004;303:1662–65.