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. 2015 Feb 19;12:15. doi: 10.1186/s12950-015-0060-9

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© de Gaetano et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CLA reduces intracellular cholesterol content of human macrophage derived foam cells. HBPMCs-derived M-CSF stimulated macrophages, following treatment with c-9,t-11-CLA, t-10,c-12-CLA, CLA blend (80:20 c-9,t-11:t-10,c-12), OA, LA or TROG were ox-LDL loaded for 4 hours and cholesterol content measured by enzymatic assay. CLA blend and c-9,t-11-CLA significantly decrease the levels of both total cholesterol (TC) and free cholesterol (FC), whilst, t-10,c-12-CLA and OA decrease the FC fraction. The effect of CLA on cholesterol trafficking is regulated by a dual mechanism involving PPARγ/LXRα-dependent. Data are expressed as % of TC or FC content over vehicle control, where *p < 0.05, **p < 0.01 and are the mean of three independent experiments.