Table 2.

Relative Hepatic mRNA Levels in High-Fat Dietary Restricted Compared to Ad Libitum–Fed Mice

	Gene	AL	DR	p value
Gluconeogenesis
Phosphoenolpyruvate carboxykinase 1	Pck1	0.67±0.07	1.05±0.14	0.035
Glucose-6-phosphatase	G6pc	1.31±0.20	3.32±0.48	0.003
Lipogenesis
Fatty acid synthase	Fasn	1.37±0.11	0.79±0.14	0.008
Stearoyl-coenzyme A desaturase 1	Scd1	1.57±0.18	0.43±0.08	<0.001
Fatty acid desaturase 1	Fads1	1.51±0.17	0.71±0.08	0.004
Heat shock proteins
Hsp70	Hspa1b	1.42±0.11	10.50±2.81	0.009
Hsc70	Hspa8	1.17±0.13	2.01±0.15	0.002
Unfolded protein response
Bip/Grp78	Hspa5	1.41±0.17	0.98±0.13	0.074
Protein disulfide isomerase	Pdia3	1.08±0.09	0.41±0.06	<0.001
Anti-oxidant defense
Catalase	Cat	0.83±0.10	0.67±0.06	0.196
Superoxide dismutase 1	Sod1	1.13±0.06	1.23±0.07	0.318
Glutathione peroxidase 1	Gpx1	0.93±0.16	1.21±0.11	0.175
Glutathione peroxidase 4	Gpx4	1.24±0.14	1.26±0.14	0.899
NAD(P)H-quinone oxidoreductase 1	Nqo1	1.06±0.18	0.85±0.11	0.337
Gamma-glutamylcysteine synthetase, heavy chain (catalytic subunit)	Gclc	1.39±0.05	1.30±0.16	0.651
Gamma-glutamylcysteine synthetase, light chain (modifier subunit)	Gclm	1.15±0.14	1.39±0.23	0.386

Values are means±standard error of the mean (SEM) from six mice per group.

AL, ad libitum–fed; DR, dietary restriction.