Table 1.

Overview of PANS Evaluation

• Family history

• Medical history and physical examination

• Psychiatric evaluation

• Infectious disease evaluation

• Assessment of symptoms and history that points to need for further evaluation of immune dysregulation (autoimmune disease, inflammatory disease, immunodeficiency)

• Neurological assessment

• Assessment of somatic symptoms, including possible sleep evaluation

• Genetic evaluation

PANS, pediatric acute-onset neuropsychiatric syndrome.