Table 3.
Family History Assessment for Youth with PANS (Examples)
| Neuro/Psychiatric |
| • Movement disorders: Tics, Tourette's syndrome, chorea |
| • Obsessive compulsive disorder, hoarding |
| • Anxiety, panic disorder, social phobia |
| • Eating disorder |
| • Alcoholism and other substance abuse or addiction problem |
| • Mood disorders: Depression, manic/depressive episodes/bipolar disorder, rages, emotional lability |
| • Schizophrenia/psychotic disorders |
| • Autism/pervasive developmental disorder |
| • Attention-deficit/hyperactivity disorder (ADHD), learning disorders, intellectual disability |
| • Personality disorders |
| Autoimmune or autoinflammatory diseases |
| • Rheumatologic |
| ○ Rheumatic fever, heart valve replacement, Sydenham chorea |
| ○ Juvenile idiopathic arthritis, rheumatoid arthritis |
| ○ Spondyloarthritis, reactive arthritis, enthesitis |
| ○ Connective tissue diseases including lupus, Sjögren's syndrome, scleroderma |
| ○ Kawasaki's disease, Henoch–Schonlein purpura, other vasculitis |
| ○ Familial Mediterranean fever, other recurrent fever syndromes |
| • Endocrinologic |
| ○ Thyroiditis, Addison's disease, Type 1 diabetes |
| • Hematologic |
| ○ Idiopathic thrombocytopenia purpura (ITP), hemolytic anemia |
| ○ Antiphospholipid (APL) antibody syndrome |
| • Neurologic |
| ○ Guillain–Barré syndrome, transverse myelitis |
| ○ Multiple sclerosis or neurolmyelitis optica (Devic's disease) |
| ○ Acute disseminate encephalomyelitis (ADEM) |
| ○ Autoimmune encephalitis, brain vasculitis |
| • Gastroenterologic |
| ○ Celiac disease |
| ○ Inflammatory bowel disease (Crohn's disease, ulcerative colitis) |
| ○ Irritable bowel syndrome, food intolerances (i.e. gluten, dairy) |
| • Dermatologic |
| ○ Alopecia, vitiligo, psoriasis |
| Recurrent infections and immunodeficiency syndromes |
| • Recurrent infections: sinusitis, tonsilitis (especially strep), pneumonia, skin infections (i.e. staph), other infections. |
| • Chronic granulomatous diseases (CGD), common variable immunodeficiency (CVID), other immunodeficiency syndromes |
| Idiopathic diseases |
| • Chronic fatigue syndrome, fibromyalgia, and other pain disorders |
PANS, pediatric acute-onset neuropsychiatric syndrome.